双(6-羟基-2-萘)二硫 | 6088-51-3

• 物质功能分类: 化学试剂 - 有机试剂 - 多环化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 双(6-羟基-2-萘)二硫
• 中文别名: 2,2-二羟基二硫代-6,6-联萘；6,6'-二硫-2,2'-二萘酚；2,2ˊ-二羟基-6,6ˊ-二萘二硫；1，1-二氯-2，2-双(4-氯苯基)乙烷；2,2'-二氯二苯基二硫化物；6,6'-二羟基-2,2'-二萘基二硫醚；6,6-二硫-2,2-二萘酚
• 英文名称: 6-hydroxy-2-naphthyldisulphide
• 英文别名: 6-Hydroxy-2-naphthyldisulfide；6-Hydroxy-2-naphthyl disulfide；6-[(6-hydroxynaphthalen-2-yl)disulfanyl]naphthalen-2-ol
• CAS: 6088-51-3
• 化学式: C₂₀H₁₄O₂S₂
• mdl: MFCD00004083
• 分子量: 350.462
• InChiKey: AHXGXXJEEHFHDK-UHFFFAOYSA-N

物化性质

• 熔点：
  226 °C
• 沸点：
  597.5±25.0 °C(Predicted)
• 密度：
  1.46±0.1 g/cm3(Predicted)
• 溶解度：
  <26.28mg/ml，溶于 DMSO

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  91.1
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 危险品标志：
  Xi
• 危险类别码：
  R36/37/38
• WGK Germany：
  3
• 海关编码：
  2930909090
• 安全说明：
  S26,S36

反应信息

• 作为反应物：
  描述：

  双(6-羟基-2-萘)二硫 生成
  参考文献：
  名称：

  Blokhin, A. P.; Gelin, M. F.; Kalosha, I. I., Journal of Applied Spectroscopy, 1999, vol. 66, # 1, p. 55 - 61

  摘要：

  DOI：
• 作为产物：
  描述：

  (6-Oxy-naphthyl-(2))-mercaptan 在 碘 作用下， 以 甲醇 、 水 为溶剂， 生成 双(6-羟基-2-萘)二硫
  参考文献：
  名称：

  Effects of oxygen–sulfur substitution on glycosaminoglycan-priming naphthoxylosides

  摘要：

  Three series of sulfur-containing analogs to the selectively antiproliferative 2-(6-hydroxynaphthyl) beta-D-xylopyranoside were synthesized and their biological properties investigated. A short, general route to hydroxynaphthyl disulfides from dihydroxy-naphthalenes was developed to utilize the disulfide bond as a sulfur-selective protecting group to enable the orthogonal protection of hydroxyls and thiols. The results indicate that hydrophobic, uncharged oxygen-sulfur substituted naphthoxylosides are taken up by calls and initiate priming of GAG chains to a greater extent compared to the oxygen analogs. No correlation between priming ability and antiproliferative activity was observed. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.05.008
• 作为试剂：
  描述：

  三缩四乙二醇 、 乙二醇 、 丙烯酸甲酯（MA） 以 双(6-羟基-2-萘)二硫 为溶剂， 生成 2-巯基丙酸甲酯
  参考文献：
  名称：

  Method for preparing mercaptopropionic acid esters

  摘要：

  提供了一种制备巯基丙酸酯的方法，该方法通过在弱碱性胺作为催化剂，聚醚作为协同催化剂，聚硫代丙酸酯作为反应溶剂，以及添加元素硫的情况下，将丙烯酸酯与氢硫化物反应。

  公开号：

  US05157147A1

文献信息

• [EN] BORONATE-MEDIATED DELIVERY OF MOLECULES INTO CELLS<br/>[FR] ADMINISTRATION DE MÉDICAMENT MÉDIÉE PAR LES BORONATE
  申请人：WISCONSIN ALUMNI RES FOUND

  公开号：WO2013110005A1

  公开（公告）日：2013-07-25

  Methods for enhancing cellular uptake of cargo molecules by boronating the cargo molecule, particularly with one or more phenylboronic acid groups. Cellular uptake includes at least partial uptake into the cytosol. Boronation includes ligating, crosslinking or otherwise bonding one or more phenylboronic acids substituted to contain a reactive group to a cargo molecule. Boronation also includes ligating, crosslinking or otherwise bonding a phenylboronated oligopeptide to a cargo molecule. The phenylboronate groups are optionally conjugated to the cargo molecule via linking moieties that can be selectively cleaved. The invention includes certain phenylboronates which are boronation reagents, certain boronated oligopeptides and certain boronated peptides and proteins. The invention also includes kits for enhancing cellular uptake of cargo molecules by boronation with one or more phenylboronates or boronated oligopeptides.

  增强货物分子细胞摄取的方法，通过将货物分子硼酸化，特别是与一个或多个苯硼酸基团硼酸化。细胞摄取至少包括部分摄取到细胞质中。硼酸化包括将一个或多个含有反应基团的取代苯硼酸与货物分子连接、交联或以其他方式键合。硼酸化还包括将苯硼酸化的寡肽与货物分子连接、交联或以其他方式键合。可选地，苯硼酸基团通过可以选择性切割的连接基团与货物分子连接。本发明包括某些作为硼酸化试剂的苯硼酸、某些硼酸化的寡肽以及某些硼酸化的肽和蛋白质。本发明还包括通过用一种或多种苯硼酸或硼酸化寡肽硼酸化来增强货物分子细胞摄取的试剂盒。
• CURATIVES FOR EPOXY ADHESIVE COMPOSITIONS
  申请人：Dershem Stephen M.

  公开号：US20100113643A1

  公开（公告）日：2010-05-06

  The invention provides epoxy and oxetane compositions including the novel acyloxy and N-acyl curing agents described herein. Use of invention curing agents result in cured adhesive compositions with remarkably increased adhesion and reduced hydrophilicity when compared to resins cured with other types of curing agents. Furthermore, the curatives of this invention do not interfere with free-radical cure and are thus suited for use in hybrid cure thermoset compositions.

  该发明提供了包括新型酰氧基和N-酰基固化剂的环氧树脂和氧环烷组合物。使用该发明的固化剂可使胶粘剂组合物固化后的粘附性大大增加，并且与用其他类型的固化剂固化的树脂相比，其亲水性减少。此外，该发明的固化剂不会干扰自由基固化，因此适用于混合固化热固性组合物的使用。
• [EN] DITHIOAMINE REDUCING AGENTS<br/>[FR] AGENTS RÉDUCTEURS DITHIOAMINE
  申请人：WISCONSIN ALUMNI RES FOUND

  公开号：WO2013123382A1

  公开（公告）日：2013-08-22

  Dithioamine reducing agents useful for the reduction of disulfide bonds. The reducing agents of this invention are useful, for example, to reduce disulfide bonds, particularly in proteins, or to prevent the formation of disulfide bonds, particularly in proteins and other biological molecules. Reducing agents of this invention can be employed to regulate protein function in proteins in which a sulfhydryl group is associated with biological activity. Reducing agents of this invention can prevent inactivation of a given protein or enhance activation of a given protein or other biological molecule in vitro and/or in vivo. Reducing agents of this invention can prevent or reduce oxidation of cysteine residues in proteins and prevent the formation of reduced activity protein dimers (or other oligomers). Reducing agents of this invention are useful and suitable for application in a variety of biological applications, particularly as research and synthetic reagents.

  硫胺类还原剂可用于还原二硫键。该发明的还原剂可用于还原二硫键，特别是蛋白质中的二硫键，或者预防二硫键的形成，特别是在蛋白质和其他生物分子中。该发明的还原剂可用于调节蛋白质功能，其中巯基与生物活性相关。该发明的还原剂可防止给定蛋白质的失活，或增强给定蛋白质或其他生物分子的活化，无论是在体外还是体内。该发明的还原剂可预防或减少蛋白质中半胱氨酸残基的氧化，并防止降低活性蛋白质二聚体（或其他寡聚体）的形成。该发明的还原剂适用于各种生物应用，特别是作为研究和合成试剂。
• Switching catalytic reaction conducted in pore void of mesoporous material by redox gate control
  作者：Masahiro Fujiwara、Shigeki Terashima、Yasuko Endo、Kumi Shiokawa、Hiroyoshi Ohue

  DOI：10.1039/b610444d

  日期：——

  A molecular gate attached on the pore outlet of a mesoporous material, which is opened and closed by redox system of thiol groups, effectively switched the progress of a catalytic reaction promoted by the acidic site in the pore void.

  一个分子门附着在介孔材料的孔口，通过硫醇基的氧化还原系统打开和关闭，有效地调控了由孔隙中的酸性位点促进的催化反应进程。
• Brønsted acid-catalyzed aromatic annulation of alkoxyallenes with naphthols: a reaction sequence to larger π-conjugated naphthopyrans with aggregation-induced emission characters
  作者：Jinlong Zhang、Lu Zhu、Kang Shen、Huameng Yang、Xiao-Chun Hang、Gaoxi Jiang

  DOI：10.1039/c8sc03837f

  日期：——

  A practical and readily scalable reaction sequence was developed for the straightforward synthesis of a new family of larger π-conjugated naphthopyrans by a Brønsted acid-catalyzed aromatic annulation of alkoxyallenes with inert naphthols. The cascade pathway involves allylation/cyclization/debenzyloxylation/isomerization/dehydration. The new class of solid state diphenylmethylene substituted naphthopyrans

  开发了一种实用且易于扩展的反应序列，用于通过布朗斯台德酸与惰性萘并烷氧基烯丙酸酯的芳族环化反应，直接合成较大的π-共轭萘并吡喃的新家族。级联途径涉及烯丙基化/环化/脱苄氧基化/异构化/脱水。新型的固态二苯基亚甲基取代的萘并吡喃具有荧光发射作用，并被证明具有聚集诱导发射（AIE）行为。

表征谱图