2,4,6-tris(4-trifluoromethylphenyl)phenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4,6-tris(4-trifluoromethylphenyl)phenol
• 英文别名: 2,4,6-Tris[4-(trifluoromethyl)phenyl]phenol
• 化学式: C₂₇H₁₅F₉O
• 分子量: 526.401
• InChiKey: UWFQJJPFPPHIGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.1
• 重原子数：
  37
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  4-三氟甲基苯硼酸 、 三溴苯酚 在 palladium diacetate sodium carbonate 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以85%的产率得到2,4,6-tris(4-trifluoromethylphenyl)phenol
  参考文献：
  名称：

  Synthesis of Biaryls and Polyaryls by Ligand-Free Suzuki Reaction in Aqueous Phase

  摘要：

  A highly efficient palladium acetate-catalyzed ligand-free Suzuki reaction in aqueous phase was developed in short reaction times (0.5-1 h) at 35 degrees C in air. The key for such a successful catalytic system was the use of a suitable amount of cosolvents in the aqueous phase. The method could be extended to the consecutive multi-Suzuki coupling, and polyaryls were prepared in a single one-pot step in high selectivity and excellent yield under mild reaction conditions (60 degrees C).

  DOI：

  10.1021/jo060122v

文献信息

• Synthesis of Biaryls and Polyaryls by Ligand-Free Suzuki Reaction in Aqueous Phase
  作者：Leifang Liu、Yuhong Zhang、Bingwei Xin

  DOI：10.1021/jo060122v

  日期：2006.5.1

  A highly efficient palladium acetate-catalyzed ligand-free Suzuki reaction in aqueous phase was developed in short reaction times (0.5-1 h) at 35 degrees C in air. The key for such a successful catalytic system was the use of a suitable amount of cosolvents in the aqueous phase. The method could be extended to the consecutive multi-Suzuki coupling, and polyaryls were prepared in a single one-pot step in high selectivity and excellent yield under mild reaction conditions (60 degrees C).