(3-ethoxycarbonyl-4,5-diphenylfuran-2-yl-methyl)triphenylphosphonium bromide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-ethoxycarbonyl-4,5-diphenylfuran-2-yl-methyl)triphenylphosphonium bromide
• 英文别名: (3-Ethoxycarbonyl-4,5-diphenylfuran-2-yl)methyl-triphenylphosphanium;bromide
• 化学式: Br*C₃₈H₃₂O₃P
• 分子量: 647.548
• InChiKey: NBMDPMPPQKVJPE-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  5.29
• 重原子数：
  43
• 可旋转键数：
  10
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  39.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (3-ethoxycarbonyl-4,5-diphenylfuran-2-yl-methyl)triphenylphosphonium bromide 、 苯甲醛 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 72.5h， 以20 mg的产率得到ethyl (E)-4,5-diphenyl-2-(2-phenylvinyl)furan-3-carboxylate
  参考文献：
  名称：

  Synthesis of 2-Alkenyl-3-(alkoxycarbonyl)furans Based on Feist−Benary Cyclocondensation of (2,4-Dioxobutylidene)phosphoranes with α-Haloketones and α-Chloracetaldehyde

  摘要：

  3-Acyl-2-alkenylfurans were prepared by "Feist-Benary cyclocondensation" of (2,4-dioxobutylidene) phosphoranes with chloracetaldehyde and alpha-haloketones and subsequent Wittig reactions.

  DOI：

  10.1021/jo061153t
• 作为产物：
  描述：

  2-氧-4-(三苯基膦)丁酸乙酯 、 2-溴-2-苯基乙酰苯 反应 1.0h， 生成 (3-ethoxycarbonyl-4,5-diphenylfuran-2-yl-methyl)triphenylphosphonium bromide
  参考文献：
  名称：

  Synthesis of 2-Alkenyl-3-(alkoxycarbonyl)furans Based on Feist−Benary Cyclocondensation of (2,4-Dioxobutylidene)phosphoranes with α-Haloketones and α-Chloracetaldehyde

  摘要：

  3-Acyl-2-alkenylfurans were prepared by "Feist-Benary cyclocondensation" of (2,4-dioxobutylidene) phosphoranes with chloracetaldehyde and alpha-haloketones and subsequent Wittig reactions.

  DOI：

  10.1021/jo061153t

文献信息

• Synthesis of 2-Alkenyl-3-(alkoxycarbonyl)furans Based on Feist−Benary Cyclocondensation of (2,4-Dioxobutylidene)phosphoranes with α-Haloketones and α-Chloracetaldehyde
  作者：Gerson Mross、Edith Holtz、Peter Langer

  DOI：10.1021/jo061153t

  日期：2006.10.1

  3-Acyl-2-alkenylfurans were prepared by "Feist-Benary cyclocondensation" of (2,4-dioxobutylidene) phosphoranes with chloracetaldehyde and alpha-haloketones and subsequent Wittig reactions.