3-(benzo[d][1,3]dioxol-5-yl)-1,2,4-oxadiazol-5(4H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 3-(benzo[d][1,3]dioxol-5-yl)-1,2,4-oxadiazol-5(4H)-one
• 英文别名: 3-(1,3-Benzodioxol-5-yl)-1,2,4-oxadiazol-5-ol；3-(1,3-benzodioxol-5-yl)-4H-1,2,4-oxadiazol-5-one
• 化学式: C₉H₆N₂O₄
• mdl: MFCD14716212
• 分子量: 206.158
• InChiKey: PXMVKXFNQDDMAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  69.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-(benzo[d][1,3]dioxol-5-yl)-1,2,4-oxadiazol-5(4H)-one 在 copper(l) iodide 、 potassium carbonate 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 4-(4-{[3-(benzo[d][1,3]dioxol-5-yl)-5-oxo-1,2,4-oxadiazol-4(5H)-yl]methyl}-1H-1,2,3-triazol-1-yl)benzoic acid
  参考文献：
  名称：

  10.1002/jhet.4835

  摘要：

  AbstractAngiotensin‐converting enzyme inhibitors are widely used in treating arterial hypertension, acting on the renin‐angiotensin‐aldosterone system and controlling blood pressure. We present a novel, greener, and faster methodology to assess the 1,2,4‐oxadiazol‐5‐one ring and perform molecular modifications to obtain angiotensin‐converting enzyme (ACE) inhibitors using this heterocyclic core. Molecular docking simulations indicate that the tested compounds exhibited an affinity for the ACE binding site, with scores comparable to the commercial inhibitor lisinopril. However, in vitro assays revealed that the compounds were ineffective in inhibiting ACE activity. The lack of inhibition may be related to the compounds' more apolar nature. These results emphasize the importance of integrating computational and experimental approaches in developing new drugs, providing valuable insights for planning future studies to optimize the activity of synthesized compounds.

  DOI：

  10.1002/jhet.4835
• 作为产物：
  描述：

  胡椒腈 在 盐酸羟胺 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 三乙胺 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 反应 7.0h， 生成 3-(benzo[d][1,3]dioxol-5-yl)-1,2,4-oxadiazol-5(4H)-one
  参考文献：
  名称：

  恶二唑酮使能的氮杂芳族伯胺的合成

  摘要：

  尽管它们具有巨大的合成和制药用途，但基于普遍适用的C–H官能化策略，氮杂芳族伯胺仍然难以获得。恶二唑酮使能的方法据报道可方便地通过炔烃通过Co（III）催化的氧化还原中性，阶跃，原子和纯化经济的CHH功能化进入N-未取代的1-氨基异喹啉。甲15 Ñ标记实验揭示了两个恶二唑酮N原子作为引导位点的有效性。可以将已安装的伯胺用作合成有用的手柄，用于附接发散的附件。

  DOI：

  10.1021/acs.orglett.6b02814

文献信息

• Oxadiazolone-Enabled Synthesis of Primary Azaaromatic Amines
  作者：Xiaolong Yu、Kehao Chen、Fan Yang、Shanke Zha、Jin Zhu

  DOI：10.1021/acs.orglett.6b02814

  日期：2016.10.21

  Despite their tremendous synthetic and pharmaceutical utility, primary azaaromatic amines remain elusive for access based on a generally applicable C–H functionalization strategy. An oxadiazolone-enabled approach is reported for convenient entry into N-unsubstituted 1-aminoisoquinolines through Co(III)-catalyzed redox-neutral, step-, atom-, and purification-economic C–H functionalization with alkynes

  尽管它们具有巨大的合成和制药用途，但基于普遍适用的C–H官能化策略，氮杂芳族伯胺仍然难以获得。恶二唑酮使能的方法据报道可方便地通过炔烃通过Co（III）催化的氧化还原中性，阶跃，原子和纯化经济的CHH功能化进入N-未取代的1-氨基异喹啉。甲15 Ñ标记实验揭示了两个恶二唑酮N原子作为引导位点的有效性。可以将已安装的伯胺用作合成有用的手柄，用于附接发散的附件。
• Cobalt-Catalyzed, Directed Intermolecular C–H Bond Functionalization for Multiheteroatom Heterocycle Synthesis: The Case of Benzotriazine
  作者：Weiping Wu、Shuaixin Fan、Tielei Li、Lili Fang、Benfa Chu、Jin Zhu

  DOI：10.1021/acs.orglett.1c01741

  日期：2021.8.6

  Transition-metal-catalyzed, directed intermolecular C–H bond functionalization is synthetically useful but heavily underexplored in multiheteroatom heterocycle synthesis. Herein we report a cobalt catalytic method for the formation of a three-nitrogen-bearing benzotriazine scaffold via the coupling of arylhydrazine and oxadiazolone. This synthetic protocol features a low-cost base metal catalyst, a

  过渡金属催化的、定向的分子间 C-H 键官能化在合成上是有用的，但在多杂原子杂环合成中却未充分探索。在此，我们报告了一种通过芳基肼和恶二唑酮偶联形成含三氮苯并三嗪支架的钴催化方法。该合成方案具有低成本的贱金属催化剂、杂环中内置的最大杂原子数、苯并三嗪的独特合成逻辑、优越的步骤经济性和广泛的底物范围。
• C–H Activation-Engaged Synthesis of Diverse Fused-Heterocycles from the Reactions of 3-Phenyl-1,2,4-oxadiazol-5(2<i>H</i>)-ones with Vinylene Carbonate
  作者：Yuerong Wang、Qingyao Zhang、Yingdi Hao、Cankun Luo、Xin Huang、Li Guo、Yong Wu

  DOI：10.1021/acs.organomet.2c00325

  日期：2022.9.12

  We report the condition-controlled C–H activation-engaged reactions of 3-phenyl-1,2,4-oxadiazol-5(2H)-ones with vinylene carbonate, straightforwardly constructing four divergent fused-heterocycles by tuning the reaction conditions in a one-pot manner.

  我们报告了 3-phenyl-1,2,4-oxadiazol-5(2 H )-ones 与碳酸亚乙烯酯的条件控制 C-H 活化参与反应，通过调整反应条件直接构建了四个不同的稠合杂环一锅法。
• Synthesis of Pyrazolidinone-Fused Benzotriazines through C–H/N–H Bond Functionalization of 1-Phenylpyrazolidinones with Oxadiazolones
  作者：Na Li、Bin Li、Fan Yu、Xinying Zhang、Xuesen Fan

  DOI：10.1021/acs.joc.3c00194

  日期：2023.7.7

  Presented herein is an efficient synthesis of pyrazolidinone-fused benzotriazines through the cascade reaction of 1-phenylpyrazolidinones with oxadiazolones. The formation of the title products is initiated by Rh(III)-catalyzed C–H/N–H bond metallation of 1-phenylpyrazolidinone and subsequent coordination with oxadiazolone followed by migratory insertion along with CO2 liberation, proto-demetallation

  本文提出了通过1-苯基吡唑烷酮与恶二唑酮的级联反应有效合成吡唑烷酮稠合苯并三嗪。标题产物的形成是由 Rh(III) 催化的 1-苯基吡唑烷酮的 C-H/N-H 键金属化引发的，随后与恶二唑酮配位，然后与 CO 2 一起迁移插入释放、原脱金属和分子内缩合。据我们所知，这是使用恶二唑酮作为易于处理的脒替代物，基于 C-H 键激活策略首次合成吡唑烷酮稠合苯并三嗪。总体而言，该新方案具有产品价值高、底物容易获得、氧化还原中性条件、合成流程简洁、效率高、与不同官能团兼容等优点。此外，该方法的实用性通过放大合成方案以及对源自百里酚和橙花醇等天然产物的底物的适用性进一步展示。
• Tertiary Amines as Temporary Masked Secondary Amines: A Direct Access to 5-Dialkylamino-1,2,4-oxadiazoles from 1,2,4-Oxadiazol-5(4H)-ones
  作者：Wong Phakhodee、Muh Alfliadhi、Mookda Pattarawarapan、Surat Hongsibsong、Nittaya Wiriya

  DOI：10.1055/s-0042-1751555

  日期：2024.5

  tertiary amines as temporary masked secondary amines to synthesize 5-dialkylamino 1,2,4-oxadiazoles via Ph3P-I2 mediated amination of 1,2,4-oxadiazol-5(4H)-ones was developed. A one-step N-dealkylative functionalization of tertiary amines with the 1,2,4-oxadiazole ring enables a convenient access to diverse 5-amino-1,2,4-oxadiazoles. Additionally, orthogonally functionalized piperazine derivatives can be