(Z)-5-((E)-3-(4-(dimethylamino)phenyl)allylidene)-2-thioxothiazolidin-4-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-5-((E)-3-(4-(dimethylamino)phenyl)allylidene)-2-thioxothiazolidin-4-one
• 英文别名: 5-[(E)-3-(4-Dimethylamino-phenyl)-prop-2-en-(Z)-ylidene]-2-thioxo-thiazolidin-4-one；(5Z)-5-[(E)-3-[4-(dimethylamino)phenyl]prop-2-enylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
• 化学式: C₁₄H₁₄N₂OS₂
• 分子量: 290.41
• InChiKey: NUIRQBZFPKGTRR-UBXZVMTISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  89.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  罗丹宁 、 3-(4-dimethylamino-phenyl)-propenal 在 sodium acetate 、 溶剂黄146 作用下， 生成 (Z)-5-((E)-3-(4-(dimethylamino)phenyl)allylidene)-2-thioxothiazolidin-4-one
  参考文献：
  名称：

  The synthesis and SAR of rhodanines as novel class C β-lactamase inhibitors

  摘要：

  beta-Lactam antibiotics such as the cephalosporins and penicillins have diminished clinical effectiveness due to the hydrolytic activity of diverse beta-lactamases, especially those in molecular classes A and C. A structure-activity relationship (SAR) study of a high-throughput screening lead resulted in the discovery of a potent and selective non-beta-lactam inhibitor of class C beta-lactamases. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00444-3

文献信息

• Design and characterization of red fluorogenic push–pull chromophores holding great potential for bioimaging and biosensing
  作者：Chenge Li、Marie-Aude Plamont、Isabelle Aujard、Thomas Le Saux、Ludovic Jullien、Arnaud Gautier

  DOI：10.1039/c6ob01612j

  日期：——

  Fluorogenic chromophores have been used recently for fluorescence reporting and biosensing. Their ability to turn on upon specific interaction with a given target has been exploited in particular for the design of fluorogen-based reporters enabling biomolecule labeling and imaging. In this paper, we report the development and exhaustive characterization of a new family of red fluorogenic push–pull chromophores

  荧光生色团最近已用于荧光报告和生物传感。它们在与给定靶标进行特异性相互作用时开启的能力已被特别用于基于氟的报告分子的设计中，从而实现了生物分子的标记和成像。在本文中，我们报告了新的红色荧光推挽生色团家族的开发和详尽表征，它们为开发基于荧光的报告基因或细胞内荧光标记物具有巨大潜力。所提出的方法是通用的，应该在发现适用于基于氟的报告分子和生物传感器设计的新型荧光染料的发现中找到普遍的适用性。
• Psyllid Attractants and Their Uses
  申请人：INSCENT, INC.

  公开号：US20130287727A1

  公开（公告）日：2013-10-31

  The present specification discloses psyllid attractants, compositions comprising such attractants, lures, traps and other devices using such attractants, methods and uses to attract, capture and/or kill psyllids using such attractants, compositions and/or lures, traps and/or other devices, and methods and uses for monitoring a psyllid population using such attractants, compositions and/or lures, traps and/or other devices.
• [EN] PSYLLID ATTRACTANTS AND THEIR USES<br/>[FR] ATTRACTEURS DE PSYLLES ET LEURS UTILISATIONS
  申请人：INSCENT INC

  公开号：WO2013163454A2

  公开（公告）日：2013-10-31

  The present specification discloses psyllid attractants, compositions comprising such attractants, lures, traps and other devices using such attractants, methods and uses to attract, capture and/or kill psyllids using such attractants, compositions and/or lures, traps and/or other devices, and methods and uses for monitoring a psyllid population using such attractants, compositions and/or lures, traps and/or other devices.