3-(furan-2-ylthio)propionic acid

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 3-(furan-2-ylthio)propionic acid
• 英文别名: 3-(2-furylthio)propionic acid；3-(Furan-2-ylsulfanyl)propanoic acid
• 化学式: C₇H₈O₃S
• 分子量: 172.205
• InChiKey: OQHIRZSOIZEPEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  75.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  呋喃 、 3-溴丙酸 、 水 在 正丁基锂 、 硫化氢 作用下， 以 四氢呋喃 、 potassium carbonate 为溶剂， 生成 3-(furan-2-ylthio)propionic acid
  参考文献：
  名称：

  Substituted furan sulfonamides as antiglaucoma agents

  摘要：

  与饱和杂环相融合的呋喃磺胺类化合物是一种对抑制碳酸酐酶有效的药物，适用于治疗眼内压升高。

  公开号：

  US05045561A1

文献信息

• Antimicrobial Devices and Compositions
  申请人：Karandikar Bhalchandra M.

  公开号：US20090035342A1

  公开（公告）日：2009-02-05

  The present invention comprises methods and compositions for antimicrobial devices comprising metal containing compositions which are resistant to heat and light discoloration. The metal containing compositions may comprise salts or complexes of silver, copper or zinc. In one aspect the compositions comprise silver salts. In another aspect, the compositions comprise silver complexes. In one aspect, the metal salts may comprise metal salts of saccharin, acesulfame, long chain fatty acids, and alkyl dicarboxylic acids. The compositions further comprise polymers which form salts or complexes with silver, copper or zinc. The methods of the present invention comprise treating devices with the metal containing compositions, including, but not limited to, such devices as woven wound care materials, catheters, patient care devices, and collagen matrices. The present invention further comprises treatment of humans and animals with the antimicrobial devices described herein.

  本发明涉及一种包括金属含量组合物的抗菌装置的方法和组合物，该组合物对热和光变色具有抗性。金属含量组合物可以包括银、铜或锌的盐或络合物。在一方面，组合物包括银盐。在另一方面，组合物包括银络合物。在一方面，金属盐可以包括糖精盐、乙酰糖胺盐、长链脂肪酸盐和烷基二羧酸盐。该组合物进一步包括与银、铜或锌形成盐或络合物的聚合物。本发明的方法包括使用金属含量组合物处理装置，包括但不限于编织伤口护理材料、导管、患者护理设备和胶原蛋白基质等装置。本发明还包括使用上述抗菌装置治疗人类和动物的方法。
• Rhizoxin derivates and their use as anti-tumor agents
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0350315A1

  公开（公告）日：1990-01-10

  Rhizoxin and rhizoxin-2-ene derivatives of formula (I): [in which: n is 1 to 25; A is an extra bond or oxygen, X is oxygen, sulphur, nitrogen or carbonyl; and R is hydrogen, carboxylic acyl having from 1 to 25 carbon atoms, alkoxycarbonyl group having from 2 to 26 carbon atoms, phosphono, alkylphosphono group in which the alkyl part has from 1 to 25 carbon atoms, dialkyl­phosphono group in which each alkyl part has from 1 to 25 carbon atoms, alkyl group having from 1 to 25 carbon atoms, aralkyl, cycloalkyl, heterocyclic, alkylthio group in which the alkyl part has from 1 to 25 carbon atoms, aralkylthio, or heterocyclylthio, or when X represents a nitrogen atom, R is R¹ and R², where R¹ and R² are hydrogen, alkyl, acyl, alkoxycarbonyl, phosphono, alkylphosphono or dialkylphosphono] have valuable anti-tumour activity. They may be prepared by acylation of rhizoxin or rhizoxin-2-ene.

  式(I)的根肿灵和根肿灵-2-烯衍生物： 其中n 为 1 至 25；A 为额外键或氧，X 为氧、硫、氮或羰基；和 R 是氢、具有 1 至 25 个碳原子的羧酰基、具有 2 至 26 个碳原子的烷氧羰基、膦酰基、烷基膦酰基（其中烷基部分具有 1 至 25 个碳原子）、二烷基膦酰基（其中每个烷基部分具有 1 至 25 个碳原子）、具有 1 至 25 个碳原子的烷基、或当 X 代表氮原子时，R 为 R¹ 和 R²，其中 R¹ 和 R²为氢、烷基、酰基、烷氧羰基、膦酰基、烷基膦酰基或二烷基膦酰基]具有重要的抗肿瘤活性。它们可通过 rhizoxin 或 rhizoxin-2-ene 的酰化反应制备。
• Antimicrobial devices and compositions
  申请人：Karandikar Bhalchandra M.

  公开号：US10251392B2

  公开（公告）日：2019-04-09

  The present invention comprises methods and compositions for antimicrobial devices comprising metal containing compositions which are resistant to heat and light discoloration. The metal containing compositions may comprise salts or complexes of silver, copper or zinc. In one aspect the compositions comprise silver salts. In another aspect, the compositions comprise silver complexes. In one aspect, the metal salts may comprise metal salts of saccharin, acesulfame, long chain fatty acids, and alkyl dicarboxylic acids. The compositions further comprise polymers which form salts or complexes with silver, copper or zinc. The methods of the present invention comprise treating devices with the metal containing compositions, including, but not limited to, such devices as woven wound care materials, catheters, patient care devices, and collagen matrices. The present invention further comprises treatment of humans and animals with the antimicrobial devices described herein.

  本发明包括用于抗菌装置的方法和组合物，其中包含耐热和耐光变色的含金属组合物。含金属的组合物可包括银、铜或锌的盐或络合物。一方面，组合物包含银盐。另一方面，组合物还包括银络合物。一方面，金属盐可包括糖精、安赛蜜、长链脂肪酸和烷基二羧酸的金属盐。组合物还包括与银、铜或锌形成盐或络合物的聚合物。本发明的方法包括用含金属的组合物处理设备，包括但不限于编织伤口护理材料、导管、病人护理设备和胶原蛋白基质等设备。本发明还包括用本文所述的抗菌装置处理人和动物。
• ANTIMICROBIAL DEVICES AND COMPOSITIONS
  申请人：ACRYMED, INC.

  公开号：EP1781098A2

  公开（公告）日：2007-05-09
• US5045561A
  申请人：——

  公开号：US5045561A

  公开（公告）日：1991-09-03