6Z-2-phenylmethyl-6-phenylmethylene-cyclohexanone

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 6Z-2-phenylmethyl-6-phenylmethylene-cyclohexanone
• 英文别名: (6Z)-2,6-dibenzylidenecyclohexan-1-one
• 化学式: C₂₀H₁₈O
• 分子量: 274.362
• InChiKey: CTKKGXDAWIAYSA-VXZDCBJUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,6-二苯亚甲基环己酮 在 N,N-dicyclohexyl-2-methyl-1-propanamine 、 Trichloro(trifluoromethylsulfonyloxy)silane 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 6Z-2-phenylmethyl-6-phenylmethylene-cyclohexanone 、 2-benzyl-6-benzylidenecyclohexanone
  参考文献：
  名称：

  A Tertiary Amine as A Hydride Donor: Trichlorosilyl Triflate-mediated Conjugate Reduction of Unsaturated Ketones

  摘要：

  Bulky tertiary amines, especially dicyclohexylisobutylamine, smoothly reduced alpha,beta-unsaturated ketones in the presence of trichlorosilyl triflate to give the corresponding saturated ketones In excellent yields. Isotope-labeling studies revealed that an alpha-hydrogen of the amine was transferred to the enones during reduction.

  DOI：

  10.1021/ol2014895

文献信息

• A Tertiary Amine as A Hydride Donor: Trichlorosilyl Triflate-mediated Conjugate Reduction of Unsaturated Ketones
  作者：Shunsuke Kotani、Kazuki Osakama、Masaharu Sugiura、Makoto Nakajima

  DOI：10.1021/ol2014895

  日期：2011.8.5

  Bulky tertiary amines, especially dicyclohexylisobutylamine, smoothly reduced alpha,beta-unsaturated ketones in the presence of trichlorosilyl triflate to give the corresponding saturated ketones In excellent yields. Isotope-labeling studies revealed that an alpha-hydrogen of the amine was transferred to the enones during reduction.