N-benzhydryl-5-methylpyridin-2-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzhydryl-5-methylpyridin-2-amine
• 化学式: C₁₉H₁₈N₂
• 分子量: 274.365
• InChiKey: UXXLFPZXHCAJDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氨基-5-甲基吡啶 、 二苯甲醇 在 cesiumhydroxide monohydrate 作用下， 反应 24.0h， 以81%的产率得到N-benzhydryl-5-methylpyridin-2-amine
  参考文献：
  名称：

  Efficient and practical catalyst-free-like dehydrative N-alkylation of amines and sulfinamides with alcohols initiated by aerobic oxidation of alcohols under air

  摘要：

  We developed simple and practical N-alkylation reactions of amines and sulfinamides with primary and secondary alcohols by using only catalytic amounts of air as the initiator without adding any external catalysts. This method has advantages of simple conditions, easy operation, and comparatively wider scope of substrates, providing an efficient and green catalyst-free-like alcohol-based dehydrative N-alkylation method. Mechanistic studies revealed that air initiated the reactions by aerobic oxidation of the alcohols to the key initiating aldehydes or ketones in the presence of bases. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.11.016

文献信息

• Visible-Light-Driven Iron-Catalyzed Intermolecular Benzylic C(sp³)–H Amination with 1,2,3,4-Tetrazoles
  作者：Yan Du、Jing-Jing Tang、Yarong Wang、Junhao Hu、Changhua Chen、Zhonggui Xiong、Yang Li、Jiangli Fan、Ming Bao、Xiaoqiang Yu

  DOI：10.1021/acs.orglett.3c04048

  日期：2024.1.26

  A visible-light-driven iron-catalyzed C(sp3)–H amination of diphenylmethane derivatives with 1,2,3,4-tetrazoles under mild conditions has been developed. The reaction proceeds with photosensitizer-free conditions and features satisfactory to good yields. Mechanistic studies revealed that the reaction proceeded via an iron–nitrene intermediate, and H atom abstraction was the rate-determining step. Computational

  开发了一种在温和条件下可见光驱动的铁催化二苯甲烷衍生物与 1,2,3,4-四唑的 C(sp 3 )–H 胺化反应。该反应在无光敏剂的条件下进行，并且具有令人满意的良好产率。机理研究表明，该反应通过铁-氮烯中间体进行，H原子的提取是速率决定步骤。计算研究表明，1,2,3,4-四唑的脱氮取决于可见光照射下1,2,3,4-四唑结合铁物种的六重基态向四重自旋态的转变。