2-(5-Methyl-3,6-dioxopiperazin-2-yl)acetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(5-Methyl-3,6-dioxopiperazin-2-yl)acetic acid
• 化学式: C₇H₁₀N₂O₄
• mdl: MFCD18633245
• 分子量: 186.17
• InChiKey: RVLCUCVJZVRNDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  95.5
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] METHOD OF USING DIKETOPIPERAZINES AND COMPOSITION CONTAINING THEM<br/>[FR] METHODE D'UTILISATION DE DICETOPIPERAZINES ET COMPOSITION CONTENANT CES SUBSTANCES
  申请人：DMI BIOSCIENCES INC

  公开号：WO2002011676A2

  公开（公告）日：2002-02-14

  The invention provides a method of inhibiting the effects of platelet activating factor (PAF). For instance, a disease or condition mediated by PAF (particularly inflammation) can be treated or platelet aggregation can be inhibited. The invention also provides a method of inhibiting the production and/or release of interleukin 8 (IL-8) by cells. The effects of PAF and the production and/or release of IL-8 are inhibited according to the invention by a compound of formula (1) wherein R?1 and R2¿ are defined in the application, or a physiologically-acceptable salt thereof. The invention also provides pharmaceutical compositions comprising these compounds.

  该发明提供了一种抑制血小板活化因子（PAF）效应的方法。例如，可以治疗由PAF介导的疾病或状况（特别是炎症），或抑制血小板聚集。该发明还提供了一种抑制细胞产生和/或释放白细胞介素8（IL-8）的方法。根据该发明，通过式（1）中的化合物抑制PAF的效应和IL-8的产生和/或释放，其中R?1和R2¿在申请中定义，或其生理上可接受的盐。该发明还提供了包含这些化合物的制药组合物。
• Method of using diketopiperazines and composition containing them
  申请人：Ampio Pharmaceuticals, Inc.

  公开号：US10039760B2

  公开（公告）日：2018-08-07

  The invention provides a method of inhibiting the effects of platelet activating factor (PAF). For instance, a disease or condition mediated by PAF (particularly inflammation) can be treated or platelet aggregation can be inhibited. The invention also provides a method of inhibiting the production and/or release of interleukin 8 (IL-8) by cells. The effects of PAF and the production and/or release of IL-8 are inhibited according to the invention by a compound of the formula: wherein R1 and R2 are defined in the application, or a physiologically-acceptable salt thereof. The invention also provides pharmaceutical compositions comprising these compounds.

  本发明提供了一种抑制血小板活化因子（PAF）作用的方法。例如，可以治疗由 PAF 介导的疾病或状况（特别是炎症），或抑制血小板聚集。本发明还提供了一种抑制细胞产生和/或释放白细胞介素 8（IL-8）的方法。根据本发明，PAF 的作用和 IL-8 的产生和/或释放可通过式中的化合物来抑制： 其中 R1 和 R2 在本申请中定义，或其生理上可接受的盐。本发明还提供了包含这些化合物的药物组合物。
• Use of low molecular weight fractions of human serum albumin in treating diseases
  申请人：Ampio Pharmaceuticals, Inc.

  公开号：US11389512B2

  公开（公告）日：2022-07-19

  The present invention provides a method of modulating various aspects of the immune system. In particular, the present invention teaches the use of diketopiperazines (DKPs) to modulate various aspects of the immune system such as, for example, inflammation, T-cells and various cytokines.

  本发明提供了一种调节免疫系统各个方面的方法。特别是，本发明教导使用二酮哌嗪（DKPs）来调节免疫系统的各个方面，例如炎症、T 细胞和各种细胞因子。
• Method of synthesizing diketopiperazines
  申请人：——

  公开号：US20020038026A1

  公开（公告）日：2002-03-28

  The invention provides a method of synthesizing a diketopiperazine of the formula: 1 wherein: R 1 is —CH 2 COR 3 , or —CH 2 CH 2 COR 3 ; R 2 is the side chain of an amino acid selected from the group consisting of glycine, alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, asparagine, glutamic acid, glutamine, lysine, hydroxylysine, histidine, arginine, phenylalanine, tyrosine, tryptophan, thyroxine, cysteine, methionine, norvaline and onithine; R 3 is —OH, —NH 2 , —OR 4 , —NHR 4 , or —NR 4 R 4 ; and each R 4 is independently an alkyl, aryl, alkylaryl, or arylalkyl.

  本发明提供了一种合成式中二酮哌嗪的方法： 1 其中 R 1 是-CH 2 COR 3 或-CH 2 CH 2 COR 3 ; R 2 是选自甘氨酸、丙氨酸、缬氨酸、亮氨酸、异亮氨酸、丝氨酸、苏氨酸、天门冬氨酸、天冬酰胺、谷氨酸、谷氨酰胺、赖氨酸、羟基赖氨酸、组氨酸、精氨酸、苯丙氨酸、酪氨酸、色氨酸、甲状腺素、半胱氨酸、蛋氨酸、去甲缬氨酸和鸟氨酸的氨基酸侧链； R 3 是-OH、-NH 2 、-OR 4 、-NHR 4 或-NR 4 R 4 且 每个 R 4 独立地为烷基、芳基、烷芳基或芳烷基。
• [EN] PHOSPHAMIDE DERIVATIVE, METHOD FOR MANUFACTURING THE SAME, AND USES THEREOF<br/>[FR] DÉRIVÉ DE PHOSPHAMIDE, SON PROCÉDÉ DE FABRICATION ET SES UTILISATIONS<br/>[ZH] 一种磷酰胺衍生物及制备方法和用途
  申请人：SICHUAN HAISCO PHARMACEUTICAL CO LTD

  公开号：WO2017133517A1

  公开（公告）日：2017-08-10

  公开了一种磷酰胺衍生物及制备方法和用途。特别公开了一种通式(I)所示化合物及其药学上可接受的盐或立体异构体 (I)，其中，G、L、Q、s如说明书中所定义。