4-methyl-2-(4-methylphenyl)-1-(4-sulphamoylphenyl)pyrrole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 4-methyl-2-(4-methylphenyl)-1-(4-sulphamoylphenyl)pyrrole
• 英文别名: 4-methyl-2-(4-methylphenyl)-1-(4-sulfamoylphenyl)pyrrole；4-[4-Methyl-2-(4-methylphenyl)pyrrol-1-yl]benzenesulfonamide
• 化学式: C₁₈H₁₈N₂O₂S
• 分子量: 326.419
• InChiKey: WJUNZALJFFIPOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  73.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] COMBINATION THERAPY FOR THE TREATMENT OF CANCER USING COX-2 INHIBITORS AND DUAL INHIBITORS OF EGFR [ERBB1] AND HER-2 [ERBB2]<br/>[FR] POLYTHÉRAPIE POUR LE TRAITEMENT DE CANCER AU MOYEN D'INHIBITEURS DE LA COX-2 ET D'INHIBITEURS DOUBLES DE L'EGFR [ERBB1] ET DE L'HER-2 [ERBB2]
  申请人：TRAGARA PHARMACEUTICALS INC

  公开号：WO2009042613A1

  公开（公告）日：2009-04-02

  Described herein are compositions and methods for using these compositions in the treatment of cancer, tumors, and tumor-related disorders in a subject.

  本文描述了一种用于治疗癌症、肿瘤和肿瘤相关疾病的组合物和使用这些组合物的方法。
• THERAPIES FOR TREATING CANCER USING COMBINATIONS OF COX-2 INHIBITORS AND AROMATASE INHIBITORS OR COMBINATIONS OF COX-2 INHIBITORS AND ESTROGEN RECEPTOR ANTAGONISTS
  申请人：Estok Thomas M.

  公开号：US20120015919A1

  公开（公告）日：2012-01-19

  Described herein are compositions and methods for using these compositions in the treatment of cancer, tumors, and tumor-related disorders in a subject.

  本文描述了一种组合物和使用这些组合物治疗受体中的癌症、肿瘤和肿瘤相关疾病的方法。
• Use of cyclooxygenase-2 inhibitors for the treatment and prevention of tumors, tumor-related disorders and cachexia
  申请人：Sankyo Company Limited

  公开号：EP0927555A1

  公开（公告）日：1999-07-07

  Certain cyclooxygenase-2 inhibitors are useful for the treatment and prevention of tumours and tumour-related disorders and cachexia.

  某些环氧化酶-2 抑制剂可用于治疗和预防肿瘤、肿瘤相关疾病和恶病质。
• Methods and compositions for the treatment and prevention of tumors, tumor-related disorders and cachexia
  申请人：Kurakata Shinichi

  公开号：US20050014814A1

  公开（公告）日：2005-01-20

  Certain cyclooxygenase-2 inhibitors are useful for the treatment and prevention of tumors and tumor-related disorders and cachexia.

  某些环氧化酶-2 抑制剂可用于治疗和预防肿瘤、肿瘤相关疾病和恶病质。
• 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP0799823B1

  公开（公告）日：2007-10-31