benzyl N-[(12S)-2-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]-13-oxo-1-azatricyclo[7.4.1.05,14]tetradeca-5,7,9(14)-trien-12-yl]carbamate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: benzyl N-[(12S)-2-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]-13-oxo-1-azatricyclo[7.4.1.05,14]tetradeca-5,7,9(14)-trien-12-yl]carbamate
• 化学式: C₂₆H₂₇N₃O₇
• 分子量: 493.5
• InChiKey: QKSILZAIUPLUGA-QXJVHLGASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  134
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] TREATMENT OF INFECTIOUS DISEASE USING INTERLEUKIN-1 BETA CONVERTING ENZYME (ICE)/CED-3 FAMILY INHIBITORS<br/>[FR] TRAITEMENT D'UNE MALADIE INFECTIEUSE A L'AIDE D'INHIBITEURS DE LA FAMILLE CED-3/ICE (ENZYME DE CONVERSION DE L'INTERLEUKINE-1 BETA)
  申请人：IDUN PHARMACEUTICALS INC

  公开号：WO2003032918A2

  公开（公告）日：2003-04-24

  The present invention provides methods and compositions for treating infectious disease or suppressing inflammation associated therewith or ameliorating symptoms thereof by the suppression of the activity of a member of the interleukin-1ß-converting enzyme (ICE)/CED-3 family of proteases. Also provided are compositions useful for these purposes. Exemplary compounds useful in the methods of the invention are provided herein.