(2R)-N-(1-benzylpiperidin-4-yl)-3-cyclohexylmethylthio-2-((4R)-3-chloromethoxycarbonylthiazolidin-4-ylcarbonylamino)propanamide · hydrochloride | 255735-56-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-N-(1-benzylpiperidin-4-yl)-3-cyclohexylmethylthio-2-((4R)-3-chloromethoxycarbonylthiazolidin-4-ylcarbonylamino)propanamide · hydrochloride
• 英文别名: chloromethyl (4R)-4-[[(2R)-1-[(1-benzylpiperidin-4-yl)amino]-3-(cyclohexylmethylsulfanyl)-1-oxopropan-2-yl]carbamoyl]-1,3-thiazolidine-3-carboxylate;hydrochloride
• CAS: 255735-56-9
• 化学式: C₂₈H₄₁ClN₄O₄S₂*ClH
• 分子量: 633.704
• InChiKey: CCOJKYCRSUSYBZ-DKIIUIKKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  40
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  142
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Amino acid derivatives and pharmaceutical composition comprising, as active ingredients, them
  申请人：Seko Takuya

  公开号：US20050009890A1

  公开（公告）日：2005-01-13

  The present invention relates to the compounds of the formula (I) and salts thereof (all the symbols are the same meanings as described in the specification). The compounds of the formula (I) possess inhibitory activity of N-type calcium channel, so they are useful as drug for prevention and/or treatment of cerebral infarct, transient ischemic attack, encephalomyelopathy after cardiac operation, spinal angiopathy, hypertension with stress, neurosis, epilepsy, asthma and pollakiuria etc. or agent for the treatment of pain.
• US6903119B1
  申请人：——

  公开号：US6903119B1

  公开（公告）日：2005-06-07
• US7427634B2
  申请人：——

  公开号：US7427634B2

  公开（公告）日：2008-09-23