(S)-1-((3,4,5-Trimethoxyphenyl)-methyl-carbamoyl)-piperidine-2-carboxylic acid 4-pyridin-3-yl-1-(3-pyridin-3-yl-propyl)-butyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-1-((3,4,5-Trimethoxyphenyl)-methyl-carbamoyl)-piperidine-2-carboxylic acid 4-pyridin-3-yl-1-(3-pyridin-3-yl-propyl)-butyl ester
• 英文别名: 1,7-dipyridin-3-ylheptan-4-yl (2S)-1-[(3,4,5-trimethoxyphenyl)methylcarbamoyl]piperidine-2-carboxylate
• 化学式: C₃₄H₄₄N₄O₆
• 分子量: 604.747
• InChiKey: KQTURYOCFFAGKZ-LJAQVGFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  44
• 可旋转键数：
  16
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  112
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Novel carbamates and ureas as modifiers of multi-drug resistance
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP1138673A2

  公开（公告）日：2001-10-04

  The present invention relates to compounds as represented by formula (I) that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also comprises pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of multi-drug resistance and for use in multi-drug resistant cancer therapy.

  本发明涉及式（I）所代表的化合物，这些化合物可以维持、增加或恢复细胞对治疗或预防药物的敏感性。本发明还包括含有这些化合物的药物组合物。本发明的化合物和药物组合物尤其适用于治疗耐多药细胞、预防耐多药以及用于耐多药癌症治疗。
• Methods and compositions for stimulating neurite growth using compounds with affinity for fkbp12 in combination with neurotrophic factors
  申请人：Vertex Pharmceuticals Incorporated

  公开号：EP1666053A1

  公开（公告）日：2006-06-07

  The present invention relates to methods and pharmaceutical compositions for stimulating the growth of neurites in nerve cells. The compositions comprise a neurotrophic amount of a compound and a neurotrophic factor, such as nerve growth factor (NGF). The methods comprise treating nerve cells with the above compositions or compositions comprising the compound without a neurotrophic factor. The methods of this invention can be used to promote repair of neuronal damage caused by disease or physical trauma.

  本发明涉及刺激神经细胞中神经元生长的方法和药物组合物。这些组合物包含一定量的神经营养化合物和神经营养因子，如神经生长因子（NGF）。本发明的方法包括用上述组合物或包含不含神经营养因子的化合物的组合物处理神经细胞。本发明的方法可用于促进由疾病或物理创伤引起的神经元损伤的修复。
• NOVEL CARBAMATES AND UREAS AS MODIFIERS OF MULTI-DRUG RESISTANCE
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP0754176B1

  公开（公告）日：2001-12-05
• NEUROPHILIN LIGANDS FOR TREATING OCULAR CONDITIONS
  申请人：Alcon, Inc.

  公开号：EP1227859B1

  公开（公告）日：2006-08-09
• Potentiators of antibacterial activity
  申请人：Grossman Hope Trudy

  公开号：US20050090482A1

  公开（公告）日：2005-04-28

  The present invention relates to compounds that potentiate the activity of antibacterials. The present invention also relates to compositions useful in treating bacterial infection in mammals, and methods therewith. The present invention also relates to a method of inhibiting bacterial efflux of an antibiotic, thereby increasing the efficacy of the antibiotic.