2-(2-oxo-pyrrolidinyl)propionic acid N-pyridin-3-ylamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(2-oxo-pyrrolidinyl)propionic acid N-pyridin-3-ylamide
• 英文别名: 2-[2-Oxo-1-pyrrolidinyl]propionic acid N-3-pyridylamide；2-(2-oxo-pyrrolidinyl)propionic. acid N-3-pyridylamide；2-(2-oxopyrrolidin-1-yl)-N-pyridin-3-ylpropanamide
• 化学式: C₁₂H₁₅N₃O₂
• 分子量: 233.27
• InChiKey: IKEJVRZKDFTLKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  62.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• MITOCHONDRIAL MEMBRANE STABILIZER
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP0953356A1

  公开（公告）日：1999-11-03

  An medicament for preventive and/or therapeutic treatment of a disease caused by mitochondrial functional abnormality, or a disease with mitochondrial functional abnormality, e.g., ischemic diseases, toxic diseases, degenerative diseases, which comprises as an active ingredient a substance having a stabilizing effect on mitochondrial membrane by stabilizing mitochondrial membrane potential, e.g., 2-oxo-1-pyrrolidinylacetic acid 2,6-dimethylanilide which acts as a benzodiazepine receptor antagonist.

  一种用于预防和/或治疗由线粒体功能异常引起的疾病或线粒体功能异常疾病（如缺血性疾病、中毒性疾病、退行性疾病）的药物，其活性成分包括通过稳定线粒体膜电位对线粒体膜具有稳定作用的物质，如线粒体膜电位稳定剂、 一种用于预防和/或治疗由线粒体功能异常引起的疾病或具有线粒体功能异常的疾病（如缺血性疾病、中毒性疾病、退行性疾病）的药物，其有效成分包括通过稳定线粒体膜电位对线粒体膜具有稳定作用的物质，如作为苯并二氮杂卓受体拮抗剂的 2-氧代-1-吡咯烷基乙酸 2,6-二甲基苯胺。
• NOOTROPIC AGENT
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP1022029A1

  公开（公告）日：2000-07-26

  A drug which improves cerebral neurotransmission based on interaction of long-term activation of a protein kinase C pathway and long-term activation of presynaptic nicotinic acetylcholine (nACh) receptors, and on an accompanying increase in the amount of released glutamate, which activates cerebral neurotransmission over a prolonged period. The substances of the present invention serve as excellent nootropics. They are particularly useful for the therapy of dementia caused by hydrocephalus, or by subdural hemorrhage.

  一种基于长期激活蛋白激酶 C 途径和长期激活突触前烟碱乙酰胆碱（nACh）受体的相互作用，以及伴随的谷氨酸释放量的增加而改善脑神经递质的药物，可长期激活脑神经递质。本发明的物质是一种极好的促智剂。它们尤其适用于治疗由脑积水或硬脑膜下出血引起的痴呆症。
• NEURONAL DEATH INHIBITORS
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP1180366A9

  公开（公告）日：2002-04-24

  The present invention relates to neuronal death inhibitors containing, as its active ingredient, a compound represented by the following formula (1): [wherein, R1 represents a hydrogen atom or a hydroxyl group,R2 represents a hydrogen atom or a methyl group, andR3 represents a pyridyl group or a phenyl group having 1 to 3 substituents which are the same or different], or acid addition salt thereof.

  本发明涉及神经元死亡抑制剂，其活性成分含有下式(1)代表的化合物：[其中，R1 代表氢原子或羟基，R2 代表氢原子或甲基，R3 代表吡啶基或具有 1 至 3 个相同或不同取代基的苯基]，或其酸加成盐。
• Neuronal death inhibitors
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：US20040077709A1

  公开（公告）日：2004-04-22

  The present invention relates to neuronal death inhibitors containing, as its active ingredient, a compound represented by the following formula (1): 1 [wherein, R 1 represents a hydrogen atom or a hydroxyl group, R 2 represents a hydrogen atom or a methyl group, and R 3 represents a pyridyl group or a phenyl group having 1 to 3 substituents which are the same or different], or acid addition salt thereof.
• US4341790A
  申请人：——

  公开号：US4341790A

  公开（公告）日：1982-07-27