(E)-(2S,3S,5R,6R)-6-Hydroxymethyl-3-methyl-3-(3-nitrilo-propenyl)-4,4,7-trioxo-4-lambda(6)-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | 283610-89-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (E)-(2S,3S,5R,6R)-6-Hydroxymethyl-3-methyl-3-(3-nitrilo-propenyl)-4,4,7-trioxo-4-lambda(6)-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid
• 英文别名: (2S,3S,5R,6R)-3-[(E)-2-cyanoethenyl]-6-(hydroxymethyl)-3-methyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid；(2S,3S,5R,6R)-3-[(E)-2-cyanoethenyl]-6-(hydroxymethyl)-3-methyl-4,4,7-trioxo-4λ6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• CAS: 283610-89-9
• 化学式: C₁₁H₁₂N₂O₆S
• 分子量: 300.292
• InChiKey: NZNHTQCXWOAKDT-SURRTWTPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  144
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• 3,6-DISUBSTITUTED PENAM SULFONE DERIVATIVES AS ANTIBACTERIALS
  申请人：American Cyanamid Company

  公开号：EP1144418A1

  公开（公告）日：2001-10-17
• US6395726B1
  申请人：——

  公开号：US6395726B1

  公开（公告）日：2002-05-28
• [EN] 3,6-DISUBSTITUTED PENAM SULFONE DERIVATIVES AS ANTIBACTERIALS<br/>[FR] DERIVES DE PENAME SULFONE 3,6-DISUBSTITUES COMME ANTIBACTERIENS
  申请人：AMERICAN CYANAMID CO

  公开号：WO2000043399A1

  公开（公告）日：2000-07-27

  Compounds are provided having formulae (I) and (II) wherein n is 0 or 1 and when n=1, R is a 5 or 6 membered heterocyclic ring, hydroxy, halogen, oxo, carbamoyl, alkoxy, or disubstituted amino, when n=0, R is an ester, cyano or amide group; X is CH or NH; R3 is cyano, methoxy, or acetamido; R1 is hydrogen, alkyl, a negative charge, a cation selected from the group consisting of sodium, potassium and tetraalkylammonium and acyloxyalkyl, or alkoxycarbonyloxyalkyl; and R2 is hydrogen, acyl, trisubstituted silyl carbamoyl or an amino acid residue; or pharmaceutically acceptable salts thereof.