Ethyl 2-[5-[4-(difluoromethoxy)phenoxy]pentyl]oxirane-2-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Ethyl 2-[5-[4-(difluoromethoxy)phenoxy]pentyl]oxirane-2-carboxylate
• 化学式: C₁₇H₂₂F₂O₅
• 分子量: 344.3
• InChiKey: HGTVFGOPAXXXPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  57.3
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Inhibitors of the fatty acid oxidation for the prophylaxis and/or the treatment of chronic and/or atopic skin diseases
  申请人：Nieland John

  公开号：US20060089406A1

  公开（公告）日：2006-04-27

  The invention relates to a method of preventing and/or treating a chronic and/or an atopic skin disease by administering an inhibitor of fatty acid oxidation to a patient in a pharmacologically effective amount. Furthermore, the invention relates to the use of at least one inhibitor of fatty acid oxidation for the preparation of a pharmaceutical composition for the prophylaxis and/or treatment of a chronic and/or an atopic skin disease.

  本发明涉及一种通过向患者施用药理有效量的脂肪酸氧化抑制剂来预防和/或治疗慢性和/或特应性皮肤病的方法。此外，本发明还涉及使用至少一种脂肪酸氧化抑制剂制备预防和/或治疗慢性和/或特应性皮肤病的药物组合物。
• OXIRANCARBONSÄUREN FÜR DIE BEHANDLUNG VON DIABETES
  申请人：Wolf, Horst P.O., Dr.

  公开号：EP0966455B1

  公开（公告）日：2004-01-28
• INHIBITORS OF THE FATTY ACID OXIDATION FOR THE PROPHYLAXIS AND/OR THE TREATMENT OF CHRONIC AND/OR ATOPIC SKIN DISEASES
  申请人：MediGene Aktiengesellschaft

  公开号：EP1549398A1

  公开（公告）日：2005-07-06
• INHIBITORS OF CARNITIN-PALMITOYL-TRANSFERASE-1 FOR THE TREATMENT AND PREVENTION OF DISORDERS CAUSED BY DELIPIDATION OF NEURAL TISSUE
  申请人：Meta-IQ APS

  公开号：EP2310003A1

  公开（公告）日：2011-04-20
• TARGETING LIPID METABOLISM AND FREE FATTY ACID (FFA) OXIDATION TO TREAT DISEASES MEDIATED BY RESIDENT MEMORY T CELLS (TRM)
  申请人：The Brigham & Women's Hospital, Inc.

  公开号：EP3755322A1

  公开（公告）日：2020-12-30