2-[2-[2-[Bis(carboxymethyl)amino]ethyl-(2-oxopropyl)amino]ethyl-(2-oxopropyl)amino]acetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[2-[2-[Bis(carboxymethyl)amino]ethyl-(2-oxopropyl)amino]ethyl-(2-oxopropyl)amino]acetic acid
• 化学式: C₁₆H₂₇N₃O₈
• 分子量: 389.4
• InChiKey: ISELFCYAGCKDMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8.2
• 重原子数：
  27
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  156
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• EVALUATION OF PRESENCE OF AND VULNERABILITY TO ATRIAL FIBRILLATION AND OTHER INDICATIONS USING MATRIX METALLOPROTEINASE-BASED IMAGING
  申请人：Lantheus Medical Imaging, Inc.

  公开号：US20150023873A1

  公开（公告）日：2015-01-22

  The invention provides, in some embodiments, methods relating to assessing increased risk of developing atrial fibrillation (AF), and/or the likelihood of responding to particular AF therapies using imaging agents comprising an MMP inhibitor linked to an imaging moiety. The invention further provides methods for evaluating the presence of the risk of developing other cardiovascular conditions and assessing the effectiveness of treatment or other intervention for such conditions by determining MMP levels.