2-[4-(3-chlorobenzyloxy)-benzylamino]-2-(3-fluorophenyl)-acetamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[4-(3-chlorobenzyloxy)-benzylamino]-2-(3-fluorophenyl)-acetamide
• 英文别名: 2-[[4-[(3-Chlorophenyl)methoxy]phenyl]methylamino]-2-(3-fluorophenyl)acetamide
• 化学式: C₂₂H₂₀ClFN₂O₂
• 分子量: 398.864
• InChiKey: MODFUWXCNUBNKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders
  申请人：Newron Pharmaceuticals S.p.A.

  公开号：EP1557166A1

  公开（公告）日：2005-07-27

  Methods of using certain α-aminoamide derivatives to treat lower urinary tract disorders. The therapeutic agents of the invention are able to reduce or even stop the lower urinary tract disorders substantially without side effects.

  使用某些α-氨基酰胺衍生物的方法来治疗下尿路障碍。该发明的治疗剂能够在没有副作用的情况下显著减少甚至停止下尿路障碍。
• Alpha-Aminoamide Derivatives Useful in the Treatment of Lower Urinary Tract Disorders
  申请人：Barbanti Elena

  公开号：US20080132567A1

  公开（公告）日：2008-06-05

  Methods of using certain α-aminoamide derivatives to treat lower urinary tract disorders. The therapeutic agents of the invention are able to reduce or even stop the lower urinary tract disorders substantially without side effects.

  使用某些α-氨基酰胺衍生物来治疗下尿路障碍的方法。本发明的治疗剂能够在几乎没有副作用的情况下显著减轻甚至停止下尿路障碍。
• Alpha-aminoamide derivatives useful as antimigraine agents
  申请人：Newron Pharmaceuticals S.p.A.

  公开号：EP1438956A1

  公开（公告）日：2004-07-21

  α-Aminoamide derivatives useful as antimigraine agents, particularly for the treatment of head pain conditions such as migraine, cluster headache or other severe headache, are disclosed. The antimigraine agents of the invention are able to reduce or even stop the pain deriving from such conditions without, virtually, any side effects.

  本发明公开了α-氨基酰胺衍生物，其可用作抗偏头痛剂，特别是用于治疗头痛症状，如偏头痛、集群头痛或其他严重头痛。本发明的抗偏头痛药物能够减轻或甚至停止由这些症状引起的疼痛，几乎没有任何副作用。
• Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders
  申请人：Newron Pharmaceuticals S.p.A.

  公开号：EP1588704A1

  公开（公告）日：2005-10-26

  Methods of using certain α-aminoamide derivatives in the treatment of RLS and addictive disorders. The compounds of this invention are able to reduce or even stop the syntoms of RLS and addictive disorders substantially without side effects.

  使用某些 α-氨基酰胺衍生物治疗 RLS 和成瘾性疾病的方法。本发明的化合物能够大大减少甚至停止 RLS 和成瘾性疾病的综合症状，而不会产生副作用。
• Alpha-aminoamide derivatives useful in the treatment of cognitive disorders
  申请人：Newron Pharmaceuticals S.p.A.

  公开号：EP1870097A1

  公开（公告）日：2007-12-26

  The present invention is in the field of pharmacotherapy of cognitive deficits in learning and memory by administering an α-aminoamide, particularly safin amide. Examples of disturbances in cognition that can be treated with compounds of the invention are the ones associated with disorders such as autism, dyslexia, attention deficit hyperactivity disorder, schizophrenia, obsessive compulsive disorders, psychosis, bipolar disorders, depression, Tourette's syndrome, Mild Cognitive Impairment (MCI) and disorders of learning in children, adolescents and adults, Age Associated Memory Impairment, Age Associated Cognitive Decline, Alzheimer's Disease, Parkinson's Disease, Down's Syndrome, traumatic brain injury Huntington's Disease, Progressive Supranuclear Palsy (PSP), HIV, stroke, vascular diseases, Pick's or Creutzfeldt-Jacob diseases, multiple sclerosis (MS), other white matter disorders and drug-induced cognitive worsening.

  本发明属于通过施用α-氨基酰胺，特别是沙芬酰胺，对学习和记忆中的认知障碍进行药物治疗的领域。本发明化合物可治疗的认知障碍包括自闭症、阅读障碍、注意缺陷多动障碍、精神分裂症、强迫症、精神病、双相情感障碍、抑郁症、抽动秽语综合征、轻度认知障碍（MCI）以及儿童、青少年和成人的学习障碍、青少年和成人的轻度认知障碍（MCI）和学习障碍、年龄相关性记忆障碍、年龄相关性认知衰退、阿尔茨海默病、帕金森病、唐氏综合症、脑外伤、亨廷顿氏病、进行性核上性麻痹（PSP）、艾滋病、中风、血管疾病、皮克氏病或克雅氏病、多发性硬化症（MS）、其他白质疾病以及药物引起的认知恶化。