(3S,5S)-4-(2-Mercaptomethyl-3-phenyl-propionylamino)-1-((S)-3-mercapto-2-methyl-propionyl)-pyrrolidine-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3S,5S)-4-(2-Mercaptomethyl-3-phenyl-propionylamino)-1-((S)-3-mercapto-2-methyl-propionyl)-pyrrolidine-2-carboxylic acid
• 英文别名: (2S,4S)-4-[(2-benzyl-3-sulfanylpropanoyl)amino]-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
• 化学式: C₁₉H₂₆N₂O₄S₂
• 分子量: 410.6
• InChiKey: BVEZVWDJQNJONB-YWQJXVSHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  88.7
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• [EN] COMPOSITIONS OF A CHROMENE OR PHENYL ACETIC ACID CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND AN ACE INHIBITOR FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DAMAGE<br/>[FR] COMPOSITIONS CONSTITUEES D'UN INHIBITEUR CHROMENE OU ACIDE PHENYLACETIQUE SELECTIF DE LA CYCLOOXYGENASE-2 ET D'UN INHIBITEUR DE ACE POUR TRAITER LES LESIONS DU SYSTEME NERVEUX CENTRAL
  申请人：PHARMACIA CORP

  公开号：WO2005016249A2

  公开（公告）日：2005-02-24

  The present invention provides compositions and methods for the treatment of central nervous system damage in a subject. More particularly, the invention provides a combination therapy for the treatment of a central nervous system ischemic condition or a central nervous system traumatic injury comprising the administration to a subject of an ACE inhibitor in combination with a chromene or phenyl acetic acid cyclooxygenase-2 selective inhibitor.