N-[(2S)-4-methyl-1-oxo-1-[[(4R)-3-oxooxan-4-yl]amino]pentan-2-yl]-5-(2-morpholin-4-ylethoxy)-1-benzofuran-2-carboxamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[(2S)-4-methyl-1-oxo-1-[[(4R)-3-oxooxan-4-yl]amino]pentan-2-yl]-5-(2-morpholin-4-ylethoxy)-1-benzofuran-2-carboxamide
• 化学式: C₂₆H₃₅N₃O₇
• 分子量: 501.6
• InChiKey: TWJGUCQVTCFUKI-RTWAWAEBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  119
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Endoluminal medical device for local delivery of cathepsin inhibitors, method of making and treating
  申请人：Biggs P. David

  公开号：US20070293937A1

  公开（公告）日：2007-12-20

  An endoluminal medical device comprises a drug release system that releases a cathepsin inhibitor at a predetermined location within a lumen of a patient. The endoluminal devices and methods of treatment of disease can treat illnesses such as aneurysms and aortic dissections.
• [EN] ENDOLUMINAL MEDICAL DEVICE FOR LOCAL DELIVERY OF CATHEPSIN INHIBITORS AND METHOD OF MAKING SUCH A DEVICE<br/>[FR] APPAREIL MÉDICAL ENDOLUMINAL POUR LIVRAISON LOCALE D'INHIBITEURS DE LA CATHEPSINE ET MÉTHODE POUR CONSTRUIRE UN TEL APPAREIL
  申请人：MED INST INC

  公开号：WO2007081530A2

  公开（公告）日：2007-07-19

  [EN] An endoluminal medical device comprises a drug release system (125) that releases a cathepsin inhibitor at a predetermined location within a lumen of a patient. The endoluminal devices and methods of treatment of disease can treat illnesses such as aneurysms.
  [FR] L'invention concerne un appareil médical endoluminal comprenant un système de libération de médicament (125) qui libère un inhibiteur de la cathepsine en un lieu prédéterminé dans une lumière d'un patient. Les appareils endoluminaux et les méthodes de traitement de maladie peuvent traiter des maladies telles que des anévrismes.