16-(16-Hydroxyhexadecoxy)hexadecanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 16-(16-Hydroxyhexadecoxy)hexadecanoic acid
• 化学式: C₃₂H₆₄O₄
• 分子量: 512.8
• InChiKey: VUZIQKIMTVEFQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.2
• 重原子数：
  36
• 可旋转键数：
  32
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Methods for ameliorating icthyosiform skin diseases
  申请人：——

  公开号：US20030072795A1

  公开（公告）日：2003-04-17

  The present invention relates to the discovery of a method to provide stabilized transglutaminase 1 enzyme, involucrin, and other molecules necessary for the assembly of the cell envelope to skin cells. Novel biological tools, prophylactics, therapeutics, cosmetics, and methods of use of the foregoing for study, prevention, and treatment of skin disorders are also disclosed.

  本发明涉及发现一种方法，以提供稳定的转谷氨酰胺酶1酶，包裹蛋白和其他必要分子以组装细胞外壳到皮肤细胞上。还公开了新的生物工具、预防药、治疗药、化妆品以及上述用于研究、预防和治疗皮肤疾病的使用方法。
• US6852686B2
  申请人：——

  公开号：US6852686B2

  公开（公告）日：2005-02-08
• [EN] METHODS FOR AMELIORATING ICTHYOSIFORM SKIN DISEASES<br/>[FR] PROCEDES D'AMELIORATION DU TRAITEMENT DES MALADIES DE LA PEAU DU TYPE ICHTYOSES
  申请人：US HEALTH

  公开号：WO2000078937A1

  公开（公告）日：2000-12-28

  The present invention relates to the discovery of a method to provide stabilized transglutaminase (1) enzyme, involucrin, and other molecules necessary for the assembly of the cell envelope to skin cells. Novel biological tools, prophylactics, therapeutics, cosmetics, and methods of use of the foregoing for study, prevention, and treatment of skin disorders are also disclosed. Further is disclosed a synthetic ceramide analog, called lipid Z and methods for its use and synthesis.