Bis-(1-naphthylmethyl)acetyl-(alpha-methyl-D-tryptophan)

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Bis-(1-naphthylmethyl)acetyl-(alpha-methyl-D-tryptophan)
• 英文别名: (2R)-3-(1H-indol-3-yl)-2-methyl-2-[[3-naphthalen-1-yl-2-(naphthalen-1-ylmethyl)propanoyl]amino]propanoic acid
• 化学式: C₃₆H₃₂N₂O₃
• 分子量: 540.6
• InChiKey: GMMGBCBAFURIRD-PSXMRANNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  41
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  82.2
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  Methyl bis-(1-naphthylmethyl)acetyl-(alpha-methyl-D-tryptophan) 、 sodium hydroxide 在 水 、 crude product 、 silica gel 、 chloroform methanol 作用下， 以 甲醇 、 1,4-二氧六环 、 水 为溶剂， 反应 96.0h， 以There was obtained 2.37 g (57.8% yield) of the product as a solid foam的产率得到Bis-(1-naphthylmethyl)acetyl-(alpha-methyl-D-tryptophan)
  参考文献：
  名称：

  Acylated amino acids as endothelin antagonists

  摘要：

  本文描述了一种拮抗内皮素的新型酰化氨基酸。其中包括制备方法和含有该化合物的制药组合物。这些化合物预计可用于治疗内皮素水平升高、急慢性肾衰竭、高血压、心肌梗死、心肌缺血、脑血管痉挛、肝硬化、脓毒性休克、充血性心力衰竭、内毒素休克、蛛网膜下腔出血、心律失常、哮喘、子痫前期、动脉粥样硬化性疾病包括雷诺氏病和再狭窄、心绞痛、癌症、肺动脉高压、缺血性疾病、胃粘膜损伤、出血性休克、缺血性肠病、糖尿病、头部损伤和中风等疾病的治疗。

  公开号：

  US05610177A1

文献信息

• METHOD AND COMPOSITION FOR TREATING DIABETIC KETOACIDOSIS
  申请人：Midwestern University

  公开号：EP2424530B1

  公开（公告）日：2015-12-16
• Method and Composition for Potentiating the Antipyretic Action of a Nonopiod Analgesic
  申请人：Gulati Anil

  公开号：US20080207763A1

  公开（公告）日：2008-08-28

  A composition and method of treating fever, and optionally treating pain, is disclosed. The composition and method utilize a nonopioid analgesic and an endothelin antagonist as active agents to treat fever in mammals, including humans. The composition also is useful in the prevention and treatment of stroke and other cardiovascular disorders, like myocardial infarction.
• Diagnostic Use of Endothelin Etb Receptor Agonists and Eta Receptor Antagonists in Tumor Imaging
  申请人：Gulati Anil

  公开号：US20080260634A1

  公开（公告）日：2008-10-23

  Methods of imaging tumors are disclosed. The methods utilize an endothelin ET B receptor agonist or an endothelin ET A receptor antagonist, in combination with an imaging agent, to detect a tumor in mammals, including humans.
• Method and Composition for Potentiating an Opiate Analgesic
  申请人：Gulati Anil

  公开号：US20100113396A1

  公开（公告）日：2010-05-06

  Composition and methods of treating pain and reducing or reversing tolerance to opiate analgesics are disclosed. The composition and method utilize an opiate analgesic and an endothelin antagonist as active agents to treat pain in mammals, including humans.
• Method and Composition for Treating Alzheimer's Disease and Dementias of Vascular Origin
  申请人：Gulati Anil

  公开号：US20100173872A1

  公开（公告）日：2010-07-08

  A composition and method of treating Alzheimer's disease or a dementia of vascular origin are disclosed. The composition and method utilize an endothelin antagonist as the active agent to treat Alzheimer's disease or a dementia of vascular origin in mammals, including humans.