2-[(2S)-2-amino-2-(1-bicyclo[2.2.1]heptanyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[(2S)-2-amino-2-(1-bicyclo[2.2.1]heptanyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
• 化学式: C₁₅H₂₁N₃O
• 分子量: 259.35
• InChiKey: GVYWNTCKOKHHAQ-CNOYCBBQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  70.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• COATED TABLET FORMULATION AND METHOD
  申请人：Astrazeneca AB

  公开号：EP3078369B1

  公开（公告）日：2019-08-21
• [EN] COATED TABLET FORMULATION AND METHOD<br/>[FR] FORMULATION DE COMPRIME REVETU ET PROCEDE CORRESPONDANT
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2005117841A1

  公开（公告）日：2005-12-15

  A coated tablet formulation is provided which includes a medicament such as the DPP4-inhibitor, saxaglipitin, formula (I), or its HCl salt, which is subject to intra-molecular cyclization, which formulation includes a tablet core containing one or more fillers, and other conventional excipients, which tablet core includes a coating thereon which may include two or more layers, at least one layer of which is an inner seal coat layer which is formed of one or more coating polymers, a second layer of which is formed of medicament which is the DPP4-inhibitor and one or more coating polymers, and an optional, but preferable third outer protective layer which is formed of one or more coating polymers. A method for forming the coated tablet is also provided.