1,1'-[Dithiobis(methylene)]biscyclopropaneacetic Acid | 162515-67-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1,1'-[Dithiobis(methylene)]biscyclopropaneacetic Acid
• 英文别名: 2-[1-[[[1-(carboxymethyl)cyclopropyl]methyldisulfanyl]methyl]cyclopropyl]acetic acid
• CAS: 162515-67-5
• 化学式: C₁₂H₁₈O₄S₂
• 分子量: 290.4
• InChiKey: CUVZSQALKWWFBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  125
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Novel process for preparing 1-(mercaptomethyl)cyclopropaneacetic acid, a useful intermediate in the preparation of montelukast and salts thereof
  申请人：Wang Yanling

  公开号：US20070208177A1

  公开（公告）日：2007-09-06

  The present invention provides a novel montelukast intermediate and a simple and straightforward process for preparing it. According to the present invention, by using this intermediate and the process, essentially as described herein, montelukast acid and salts thereof are obtained.

  本发明提供了一种新型的蒙特卢卡斯中间体和一种简单直接的制备方法。根据本发明，通过使用本中间体和所述方法，可以获得蒙特卢卡斯酸及其盐，其基本上如此描述。
• PROCESS FOR PURE MONTELUKAST SODIUM THROUGH PURE INTERMEDIATES AS WELL AS NOVEL AMINE SALTS
  申请人：Satyanarayana Reddy Manne

  公开号：US20100056793A1

  公开（公告）日：2010-03-04

  The present invention provides an improved process for the preparation of highly pure montelukast sodium through highly pure diol intermediate compound of formula (2) and (1)-(mercapto methyl)cyclopropane acetic acid methyl ester compound of formula (4) or mercaptomethyl cyclopropane acetic acid compound of formula (7). The present invention also provides novel organic amine salts of montelukast.
• US5534651A
  申请人：——

  公开号：US5534651A

  公开（公告）日：1996-07-09
• US7572930B2
  申请人：——

  公开号：US7572930B2

  公开（公告）日：2009-08-11
• US8115004B2
  申请人：——

  公开号：US8115004B2

  公开（公告）日：2012-02-14