11,11,12,12,12-pentafluorododecanoic Acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 11,11,12,12,12-pentafluorododecanoic Acid
• 化学式: C₁₂H₁₉F₅O₂
• 分子量: 290.27
• InChiKey: OEKIEEPOITUPSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  19
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Surfactant compounds and uses thereof
  申请人：——

  公开号：US20040234556A1

  公开（公告）日：2004-11-25

  A pharmaceutical aerosol formulation comprising a particulate medicament, one or more fluorocarbon or hydrogen-containing fluorocarbon propellants and a compound of the general formula (I) or a salt or solvate thereof, wherein A represents a straight chain C 1-16 alkylene substituted by n groups of formula B; n represents an integer 1 to 3; and B independently represents C 1-4 fluoroalkylC 0-6 alkylene-, C 1-4 fluoroalkylC 0-6 alkylene-O—, or C 1-4 alkylC 0-6 alkylene-O— wherein at least one substituent of formula B contains at least one fluorine atom and each C 1-4 fluoroalkyl- moiety contains one or more fluorine atoms but not more than 3 consecutive perfluorinated carbon atoms. The invention also extends to uses of compounds of formula (I) and certain novel compounds within the definition of formula (I). 1

  一种制药气雾剂配方，包括颗粒状药物、一种或多种氟碳或含氢氟碳喷射剂和通式（I）的化合物或其盐或溶剂物，其中A代表被n个B式基团取代的直链C1-16烷基；n代表整数1至3；B独立地表示C1-4氟烷基C0-6烷基、C1-4氟烷基C0-6烷基-O-，或C1-4烷基C0-6烷基-O-，其中式B的至少一个取代基含有至少一个氟原子，每个C1-4氟烷基基团含有一个或多个氟原子，但不超过3个连续的全氟碳原子。本发明还涉及使用式（I）化合物和某些新颖的符合式（I）定义的化合物。
• SURFACTANT COMPOUNDS AND USES THEREOF
  申请人：GLAXO GROUP LIMITED

  公开号：EP1411896B1

  公开（公告）日：2006-03-22
• US7195752B2
  申请人：——

  公开号：US7195752B2

  公开（公告）日：2007-03-27
• [EN] SURFACTANT COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSES D'AGENTS DE SURFACE ET LEURS UTILISATIONS
  申请人：GLAXO GROUP LTD

  公开号：WO2003013610A2

  公开（公告）日：2003-02-20

  A pharmaceutical aerosol formulation comprising a particulate medicament, one or more fluorocarbon or hydrogen-containing fluorocarbon propellants and a compound of the general formula (I) or a salt or solvate thereof, wherein A represents a straight chain C1-16 alkylene substituted by n groups of formula B; n represents an integer 1 to 3; and B independently represents C1-4 fluoroalkylC0-6 alkylene-, C1-4 fluoroalkylC0-6 alkylene-O-, or C1-4 alkylC0-6 alkylene-O- wherein at least one substituent of formula B contains at least one fluorine atom and each C1-4 fluoroalkyl- moiety contains one or more fluorine atoms but not more than 3 consecutive perfluorinated carbon atoms. The invention also extends to uses of compounds of formula (I) and certain novel compounds within the definition of formula (I).