(2S)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-2-formamido-4-methylpentanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-2-formamido-4-methylpentanamide
• 化学式: C₁₄H₂₇N₃O₃
• 分子量: 285.38
• InChiKey: PRDZJLWNCSCUKR-WDEREUQCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  87.3
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• PROCESS FOR THE PREPARATION OF A DIPEPTIDE AND INTERMEDIATE PRODUCT IN SUCH A PROCESS
  申请人：DSM N.V.

  公开号：EP1224211B1

  公开（公告）日：2003-04-16
• [EN] PROCESS FOR THE PREPARATION OF A DIPEPTIDE AND INTERMEDIATE PRODUCT IN SUCH A PROCESS<br/>[FR] PROCEDE DE PREPARATION D'UN DIPEPTIDE ET D'UN PRODUIT INTERMEDIAIRE DANS UN TEL PROCEDE
  申请人：DSM NV

  公开号：WO2001030807A1

  公开（公告）日：2001-05-03

  Process for the preparation of an N-formyl-L-leucyl-L-tert.-leucine-N-methylamide in which N-formyl L-leucine is coupled to L-tert.-leucine-N-methylamide in the presence of an activating agent. Preferably, use is made of L-tert.-leucine-N-methylamide with an enantiomeric excess greater than 98 % and N-formyl-L-leucine with an enantiomeric excess greater than 98 %. If desired, the dipeptide obtained is subsequently deformylated and the resulting N-formyl-L-tert.-leucine-N-methylamide or the L-leucyl-L-tert.-leucine-N-methylamide is further subjected to one or more crystallizations. The invention also relates to the N-formyl-L-leucyl-L-tert.-leucine-N-methylamide and the use of N-formyl-L-leucyl-L-tert.-leucine-N-methylamide in the preparation of pharmaceuticals.