N-Dodecanoyl-DL-leucine | 97850-50-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Dodecanoyl-DL-leucine
• 英文别名: N-lauroyl leucine；Lauroylleucin；2-(dodecanoylamino)-4-methylpentanoic acid
• CAS: 97850-50-5
• 化学式: C₁₈H₃₅NO₃
• 分子量: 313.481
• InChiKey: CDOCNWRWMUMCLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  22
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• METHOD FOR PRODUCTION OF L-LYSINE USING METHANOL-UTILIZING BACTERIUM
  申请人：Gunji Yoshiya

  公开号：US20100190216A1

  公开（公告）日：2010-07-29

  A method for production of L-lysine is provided which includes the steps of cultivating a methanol-utilizing bacterium in a culture medium to produce and accumulate L-lysine in the culture medium and collecting the L-lysine from the culture medium, wherein the methanol-utilizing bacterium contains DNA encoding dihydrodipicolinate synthetase which is desensitized to feedback inhibition by L-lysine and DNA encoding a LysE protein that can enhance the excretion of L-lysine out of the methanol-utilizing bacterium, and the bacterium is modified so as to increase the intracellular activities of diaminopimelic acid dehydrogenase, diaminopimelic acid decarboxylase, dihydrodipicolinic acid reductase and aspartate-semialdehyde dehydrogenase.

  提供了一种生产L-赖氨酸的方法，包括以下步骤：在培养基中培养甲醇利用的细菌，以在培养基中产生和积累L-赖氨酸，并从培养基中收集L-赖氨酸。其中，甲醇利用的细菌包含编码对L-赖氨酸反馈抑制不敏感的二氢二氢吡啶酸合成酶的DNA和编码可以增强L-赖氨酸从甲醇利用的细菌中排出的LysE蛋白的DNA，并且对细菌进行改造，以增加二氨基戊二酸脱氢酶、二氨基戊二酸脱羧酶、二氢二氢吡啶酸还原酶和天冬氨酸半醛脱氢酶的细胞内活性。
• Method for Producing an L-Amino Acid
  申请人：AJINOMOTO CO., INC.

  公开号：US20130084609A1

  公开（公告）日：2013-04-04

  An L-amino acid is produced by culturing a bacterium having an L-amino acid-producing ability in a medium containing a processed product of a microalga which promotes production and accumulation of the L-amino acid by the bacterium. The process product is produced by disrupting the culture of the microalga, and/or extracting the culture of the microalga, or fractionating the culture of the microalga or the disrupted culture. The processed product contains a mixture of organic substances produced by the microalga, a hydrolysate of the disrupted microalga culture, and/or an extract or fractionation product of the microalga culture. The processed product can also contain a saccarification product of starch or a hydrolysate of fats and oils. The bacterium is cultured to produce and accumulate the L-amino acid in culture, and the L-amino acid is collected from the culture.

  通过在含有处理过的微藻产物的培养基中培养具有L-氨基酸产生能力的细菌，可以生产出L-氨基酸。处理过的微藻产物通过破坏微藻的培养物、提取微藻的培养物或分离微藻的培养物或破坏培养物的混合物来生产。处理过的产物包含微藻产生的有机物混合物、破坏的微藻培养物的水解产物和/或微藻培养物的提取物或分离产物。处理过的产物还可以包含淀粉的糖化产物或脂肪和油的水解产物。细菌在培养基中培养以产生和积累L-氨基酸，并从培养物中收集L-氨基酸。
• METHOD FOR PRODUCING AN L-AMINO ACID
  申请人：Suzuki Shigeo

  公开号：US20110014663A1

  公开（公告）日：2011-01-20

  An L-amino acid is produced by culturing a bacterium having an L-amino acid-producing ability in a medium containing a processed product of a microalga which promotes production and accumulation of the L-amino acid by the bacterium. The process product is produced by disrupting the culture of the microalga, and/or extracting the culture of the microalga, or fractionating the culture of the microalga or the disrupted culture. The processed product contains a mixture of organic substances produced by the microalga, a hydrolysate of the disrupted microalga culture, and/or an extract or fractionation product of the microalga culture. The processed product can also contain a saccarification product of starch or a hydrolysate of fats and oils. The bacterium is cultured to produce and accumulate the L-amino acid in culture, and the L-amino acid is collected from the culture.

  使用一种含有L-氨基酸生产能力的细菌在含有一种微藻的加工产品的培养基中培养，该微藻促进细菌产生和积累L-氨基酸。加工产品是通过破坏微藻的培养物、提取微藻的培养物或分离微藻或破碎的培养物的混合物产生的。加工产品包含微藻产生的有机物混合物、破碎的微藻培养物的水解物和/或微藻培养物的提取物或分离产物。加工产品还可以包含淀粉的糖化产物或脂肪和油的水解物。细菌被培养以在培养物中产生和积累L-氨基酸，然后从培养物中收集L-氨基酸。
• VARIANT ASPARTOKINASE GENE
  申请人：Ajinomoto Co., Inc.

  公开号：EP0699759A1

  公开（公告）日：1996-03-06

  A transformant with an increased rate of L-lysine production and secretion is obtained by introducing into a corynebacterium a recombinant DNA that can be replicated in a corynebacterium and contains either a DNA fragment originating in a corynebacterium and coding for an aspartokinase α-subunit protein whereby a synergistic feedback inhibition by L-lysine and L-threonine is released or a DNA fragment originating in a corynebacterium and coding for an aspartokinase β-subunit protein whereby a synergistic feedback inhibition by L-lysine and L-threonine is released. The obtained transformant is cultured in a suitable medium and the formed L-lysine is separated.

  通过向球菌中导入可在球菌中复制的重组 DNA，获得一种 L-赖氨酸产生和分泌率增加的转化体，该 DNA 含有源自球菌并编码天冬激肽酶 α-亚基蛋白的 DNA 片段或源自球菌并编码天冬激肽酶 α-亚基蛋白的 DNA 片段。亚基蛋白，从而释放出 L-赖氨酸和 L-苏氨酸的协同反馈抑制作用；或含有 DNA 片段，该 DNA 片段源于球杆菌，编码天冬激肽酶 β-亚基蛋白，从而释放出 L-赖氨酸和 L-苏氨酸的协同反馈抑制作用。将获得的转化子在适当的培养基中培养，并分离形成的 L-赖氨酸。
• PROCESS FOR PRODUCING L-LYSINE
  申请人：Ajinomoto Co., Inc.

  公开号：EP0754756A1

  公开（公告）日：1997-01-22

  A coryneform bacterium having a high L-lysine productivity is provided by integrating a gene coding for a coryneform-origin aspartokinase released of feedback inhibition caused by L-lysine and L-threonine into a DNA of a chromosome of a coryneform bacterium carrying attenuated homoserine dehydrogenase or a coryneform bacterium deficient in a homoserine dehydrogenase gene.

  一种具有高 L-赖氨酸生产率的棒状杆菌，是通过将编码可释放 L-赖氨酸和 L-苏氨酸引起的反馈抑制作用的棒状天冬激酶的基因整合到携带减弱的均丝氨酸脱氢酶的棒状杆菌或缺乏均丝氨酸脱氢酶基因的棒状杆菌的染色体的 DNA 中而实现的。