NGR | 152880-65-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: NGR
• 英文别名: Asn-Gly-Arg；(2S)-5-(diaminomethylideneamino)-2-[[2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]acetyl]amino]pentanoic acid
• CAS: 152880-65-4
• 化学式: C₁₂H₂₃N₇O₅
• 分子量: 345.359
• InChiKey: DDPXDCKYWDGZAL-BQBZGAKWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.6
• 重原子数：
  24
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  229
• 氢给体数：
  7
• 氢受体数：
  7

文献信息

• TARGETED XTEN CONJUGATE COMPOSITIONS AND METHODS OF MAKING SAME
  申请人：Amunix Operating Inc.

  公开号：EP3218390A2

  公开（公告）日：2017-09-20
• [EN] TARGETED XTEN CONJUGATE COMPOSITIONS AND METHODS OF MAKING SAME<br/>[FR] COMPOSITIONS DE CONJUGUÉS XTEN CIBLÉS ET LEURS PROCÉDÉS DE FABRICATION
  申请人：AMUNIX OPERATING INC

  公开号：WO2016077505A2

  公开（公告）日：2016-05-19

  The present disclosure provides drug conjugate compositions, and compositions and methods for preparing and using the same. In some embodiments, the present invention relates to targeted conjugate compositions comprising cysteine -containing domains (CCD) linked to targeting moieties, extended recombinant polypeptides (XTEN) and peptide cleavable moieties, with pharmacologically active payload drugs cross-linked to cysteine residues, resulting in compositions that can be cleaved by proteases associated with target tissues. The invention also provides methods of making the targeted conjugate compositions and methods of using the targeted conjugate compositions.