2-(2-chloro-ethyl)-5,6-bis-(4-methoxy-phenyl)-2H-pyridazin-3-one | 70768-95-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(2-chloro-ethyl)-5,6-bis-(4-methoxy-phenyl)-2H-pyridazin-3-one
• 英文别名: 2-(2-Chloroethyl)-5,6-bis(4-methoxyphenyl)pyridazin-3-one
• CAS: 70768-95-5
• 化学式: C₂₀H₁₉ClN₂O₃
• 分子量: 370.835
• InChiKey: KOWNJXWOSDUXGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  51.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(2-hydroxy-ethyl)-5,6-bis-(4-methoxy-phenyl)-2H-pyridazin-3-one 、 氯化亚砜 以57%的产率得到
  参考文献：
  名称：

  NANNINI G.; BIASOII G.; PERRONE E.; FORGIONE A.; BUTTINONI A.; FERRARI M., EUR. J. MED. CHEM. CHIM. THER., 1979, 14, NO 1, 53-60

  摘要：

  DOI：

文献信息

• [EN] SUBSTITUTED 5,6-DIPHENYL-3(2H)-PYRIDAZINONES FOR USE AS FUNGICIDES<br/>[FR] 5,6-DIPHÉNYL-3 (2H)-PYRIDAZINONES SUBSTITUÉES DESTINÉES À ÊTRE UTILISÉES COMME FONGICIDES
  申请人：FMC CORP

  公开号：WO2021163519A1

  公开（公告）日：2021-08-19

  Disclosed are compounds of Formula (1) including all geometric and stereoisomers, N-oxides, and salts thereof, wherein W, R1, R2, R3, R4, R5 m, n and p are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (1) and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.

  公开了包括所有几何和立体异构体、N-氧化物和盐的化合物的结构式（1），其中W、R1、R2、R3、R4、R5、m、n和p的定义如公开内容所述。还公开了含有结构式（1）化合物的组合物以及用于控制由真菌病原体引起的植物疾病的方法，包括施用本发明的化合物或组合物的有效量。
• NOVEL PYRIDAZINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS EFFECTIVE INGREDIENTS
  申请人：OHKUCHI Masao

  公开号：US20090270399A1

  公开（公告）日：2009-10-29

  This invention relates to pyridazine derivatives represented by the formula (1): wherein R 1 represents a (substituted) aryl group, R 2 represents a phenyl group substituted at 4-position by a lower alkoxyl, group or a lower alkylthio group, R 3 represents a lower alkoxyl group, a halogenated lower alkyl group, a lower cycloalkyl group, a (substituted) aryl group, a (substituted) aryloxy group, a (substituted) nitrogen-containing heterocyclic ring residue, a (substituted) aminocarbonyl group or a lower alkylcarbonyl group, A represents a single bond, a lower alkylene group or a lower alkenylene group, X represents O or S, and the dashed line indicates that the carbon-carbon bond between the 4-position and the 5-position is a single bond or a double bond, or salts thereof; and also to medicines containing them as effective ingredients. These compounds have excellent inhibitory activity against interleukin-1β production, and are useful as preventives and therapeutics for immune system diseases, inflammatory diseases, ischemic diseases and the like.

  本发明涉及由式（1）表示的吡嗪衍生物： 其中R1表示（取代的）芳基基团，R2表示在4位被低烷氧基团或低烷硫基团取代的苯基基团，R3表示低烷氧基团、卤代的低烷基团、低环烷基团、（取代的）芳基基团、（取代的）芳氧基基团、（取代的）含氮杂环环残基、（取代的）氨基甲酰基团或低烷基甲酰基团，A表示单键、低烷基烷基或低烯基烷基，X表示O或S，虚线表示4位和5位之间的碳-碳键为单键或双键，或其盐；以及含有它们作为有效成分的药物。这些化合物具有优异的抑制白细胞介素-1β产生的活性，可用作预防和治疗免疫系统疾病、炎症性疾病、缺血性疾病等。
• SUBSTITUTED 5,6-DIPHENYL-3(2H)-PYRIDAZINONES FOR USE AS FUNGICIDES
  申请人：FMC CORPORATION

  公开号：EP4103554A1

  公开（公告）日：2022-12-21
• NANNINI G.; BIASOII G.; PERRONE E.; FORGIONE A.; BUTTINONI A.; FERRARI M., EUR. J. MED. CHEM. CHIM. THER., 1979, 14, NO 1, 53-60
  作者：NANNINI G.、 BIASOII G.、 PERRONE E.、 FORGIONE A.、 BUTTINONI A.、 FERRARI M.

  DOI：——

  日期：——