2-[(E)-[1-(4-chlorophenyl)pyrrol-2-yl]methylideneamino]guanidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-[(E)-[1-(4-chlorophenyl)pyrrol-2-yl]methylideneamino]guanidine
• 化学式: C₁₂H₁₂ClN₅
• 分子量: 261.71
• InChiKey: RYUKQNHMWPLSIM-LZYBPNLTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  81.7
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• EP1414440A1
  申请人：——

  公开号：EP1414440A1

  公开（公告）日：2004-05-06
• N-PHENYLPYRROLE GUANIDINE DERIVATIVES AS MELANOCORTIN RECEPTOR LIGANDS
  申请人：Action Pharma A/S

  公开号：EP1414440B1

  公开（公告）日：2007-01-10
• N-phenylpyrrole guanidine derivatives as melanocortin receptor ligands
  申请人：——

  公开号：US20040254093A1

  公开（公告）日：2004-12-16

  The present invention provides novel compounds of the general Formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: 1 wherein X is (CH 2 ) n where n is 0, 1 or 2; R 1 , R 2 , R 3 , R 4 and R 5 may be the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, alkoxy having 1 to 5 carbon atoms, hydroxy, alkylsulphonyloxy, cyano, nitro, trihaloalkyl, sulpho or one of the structures given in Scheme 1; or two of R 1 , R 2 , R 3 , R 4 and R 5 may together form a methylenedioxy or ethylenedioxy moiety; 2 R 6 , R 7 , R 8 and R 9 are the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, alkoxy having 1 to 5 carbon atoms, hydroxy, amines (primary, secondary or tertiary) having 0, 1 or 2 carbon atoms, cyano, nitro, trihaloalkyl, amide or sulpho, and z where shown represents the point of attachment of the residue to the phenyl or pyrrole ring; and the pharmacologically active salts thereof.
• US7186748B2
  申请人：——

  公开号：US7186748B2

  公开（公告）日：2007-03-06
• US7442807B2
  申请人：——

  公开号：US7442807B2

  公开（公告）日：2008-10-28