11,13-Octadecadienoic acid, (11E,13E)-

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 11,13-Octadecadienoic acid, (11E,13E)-
• 英文别名: (11E,13E)-octadeca-11,13-dienoic acid
• 化学式: C₁₈H₃₂O₂
• 分子量: 280.4
• InChiKey: JGFMXQLVWUGIPI-BSWSSELBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  20
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] PRODUCTION AND PURIFICATION OF ESTERS OF CONJUGATED LINOLEIC ACIDS<br/>[FR] FABRICATION ET PURIFICATION D'ESTERS D'ACIDES LINOLEIQUES CONJUGUES
  申请人：STEPAN CO

  公开号：WO2005067888A1

  公开（公告）日：2005-07-28

  A process to refine esters of conjugated linoleic acids via distillation in a single or multi-pass distillation operation is provided. Thermal rearrangement of conjugated linoleic acid components during distillation is prevented or reduced by the use of a low residence time and/or reduced pressure distillation apparatus. A process to produce refined esters of conjugated linoleic acids is also provided. The process transesterifies a linoleic acid-containing oil to generate an alkyl ester composition which further undergoes isomerization at a temperatures typically between about 90-140 °C to form an ester stream containing conjugated linoleic acid esters, which is then distilled to obtain the refined esters of conjugated linoleic acids. The transesterification and isomerization steps can be performed in one reaction vessel without an intervening distillation step. The transesterification and isomerization steps can occur concurrently in a continuous reaction system using a dual reaction zone apparatus. Refined ester compositions produced by the processes and enriched in desirable conjugated linoleic acid isomers are also contemplated.

  提供了一种通过单通或多通蒸馏操作来精制共轭亚油酸酯的过程。通过使用低停留时间和/或降低压力的蒸馏设备，可以防止或减少共轭亚油酸组分在蒸馏过程中的热重排。还提供了一种生产精制共轭亚油酸酯的过程。该过程通过酯交换将含亚油酸的油转化为生成烷基酯组合物，然后在通常在约90-140°C之间的温度下进行异构化，形成含有共轭亚油酸酯的酯流，然后对其进行蒸馏以获得精制的共轭亚油酸酯。酯交换和异构化步骤可以在一个反应容器中进行，而无需中间的蒸馏步骤。酯交换和异构化步骤可以在连续反应系统中同时进行，使用双反应区设备。此外，还考虑了由这些过程产生的富含理想共轭亚油酸异构体的精制酯组合物。
• Process for preparing conjugated linoleic acid
  申请人：Rubin David

  公开号：US20060178521A1

  公开（公告）日：2006-08-10

  Trans-9,cis-11-octadecadienoic acid is produced by forming a urea inclusion complex with cis-linoleic acid, treating the complex with a catalytic amount of a base, and recovering the trans-9,cis-11 octadecadienoic acid. Tans-10,cis-12-octadecadienoic acid is produced by iodinating cis-linoleic acid at temperatures of about −5-20° C. A mixture of trans-9,cis-11 octadecadienoic acid and trans-10,cis-12-octadecadienoic acid comprising is produced by iodinating cis-linoleic acid at temperatures ranging from about 50 to about 90° C.

  通过与顺式亚麻酸形成脲包合物，用催化剂量的碱处理该复合物，并回收反式-9，顺式-11-十八碳二烯酸来生产反式-9，顺式-11-十八碳二烯酸。在约-5-20°C的温度下，通过对顺式亚麻酸进行碘化来生产反式-10，顺式-12-十八碳二烯酸。在约50到约90°C的温度范围内，通过对顺式亚麻酸进行碘化来生产反式-9，顺式-11-十八碳二烯酸和反式-10，顺式-12-十八碳二烯酸的混合物。
• Process for Enzymatic Production of Triglycerides
  申请人：Galante Jenifer Heydinger

  公开号：US20090131701A1

  公开（公告）日：2009-05-21

  A process for enzymatic production of glyceride compositions, specifically industrially practicable production of triglycerides, including conjugated linoleic and linolenic acid triglycerides, and the compositions produced by such process. An enzymatic reaction zone is first utilized, in which a mixture of glycerol and fatty acids or fatty acid derivatives is reacted in the presence of an enzymatic catalyst to form 1,3 diglycerides. The mixture is then circulated through a second thermal rearrangement zone, maintained at a higher temperature, to promote rearrangement of the 1,3 diglycerides to 1,2 diglycerides. Triglycerides are produced by re-circulating the mixture through the enzymatic production zone.

  一种用酶生产甘油酯组合物的方法，特别是工业实用生产三酰甘油，包括共轭亚油酸和亚麻酸三酰甘油，以及由此过程产生的组合物。首先利用一个酶反应区，在酶催化剂的存在下，反应甘油和脂肪酸或脂肪酸衍生物的混合物，形成1,3-二甘油酯。然后将混合物循环通过第二个热重排区，保持较高温度，促进1,3-二甘油酯向1,2-二甘油酯的重排。通过将混合物再循环通过酶生产区，生产三酰甘油。
• Conjugated linoleic acid compositions
  申请人：ConLinCo, Inc.

  公开号：EP0950410A1

  公开（公告）日：1999-10-20

  Novel compositions containing conjugated linoleic acids are efficacious as animal feed additives and human dietary supplements. Linoleic acid is converted to its conjugated forms in which the resulting composition is low in certain unusual isomers compared to conventional conjugated linoleic products.

  含有共轭亚油酸的新型组合物可有效用作动物饲料添加剂和人类膳食补充剂。亚油酸被转化为共轭形式，与传统的共轭亚油酸产品相比，其成分中某些不常见的异构体含量较低。
• Method for the diagnosis of alzheimer s disease and mild cognitive impairment
  申请人：Biocross, S.L.

  公开号：EP2950102A1

  公开（公告）日：2015-12-02

  The invention relates to methods for determining the likelihood that a patient with mild cognitive impairment develops Alzheimer's disease based on the determination of the levels of different metabolites, including amino acids, proteins and lipids. The invention also provides a method for diagnosing Alzheimer's disease or mild cognitive impairment in a subject based on the determination of the above metabolites.

  本发明涉及根据不同代谢物（包括氨基酸、蛋白质和脂质）水平的测定来确定轻度认知障碍患者患阿尔茨海默病可能性的方法。本发明还提供了一种根据上述代谢物的测定诊断阿尔茨海默病或轻度认知障碍的方法。