(3Z)-1-(2-aminoacetyl)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]indol-2-one

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3Z)-1-(2-aminoacetyl)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]indol-2-one
• 化学式: C₁₇H₁₇N₃O₂
• 分子量: 295.34
• InChiKey: YRTIOOYSGOLRJQ-JYRVWZFOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  79.2
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• POLYMERIC CONJUGATES OF AROMATIC AMINE CONTAINING COMPOUNDS INCLUDING RELEASABLE UREA LINKER
  申请人：Zhao Hong

  公开号：US20120289571A1

  公开（公告）日：2012-11-15

  The present invention relates to releasable urea linker systems involving amine-containing chemical compounds and biologically active agents. In particular, the present invention relates to reversibly releasable linkers based on intramolecular cyclization-assisted releasable urea linkages to aromatic amine-containing compounds. The present invention also relates to polymeric conjugates of indolinone-based tyrosine kinase inhibitors.