2-(1H-benzimidazol-2-ylmethyl)-1H-benzimidazol-4-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-(1H-benzimidazol-2-ylmethyl)-1H-benzimidazol-4-ol
• 化学式: C₁₅H₁₂N₄O
• 分子量: 264.28
• InChiKey: HGCMOODMJVQBPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  77.6
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Compositions for treating ischemia-related neuronal damage
  申请人：——

  公开号：US20040072862A1

  公开（公告）日：2004-04-15

  Compounds, pharmaceutical compositions, and methods of use are described which are effective in inhibiting cell death, particularly apoptotic cell death. The compositions may be used for prevention and treatment of injuries associated with cell death, including ischemia, such as results from stroke or myocardial infarction, trauma, neurodegeneration, and inflammation.

  本文描述了一种有效抑制细胞死亡，特别是凋亡性细胞死亡的化合物、药物组合物和使用方法。这些组合物可用于预防和治疗与细胞死亡相关的损伤，包括缺血，如中风或心肌梗死引起的损伤，创伤，神经退行性疾病和炎症。
• [EN] COMPOSITIONS CONTAINING 2, 2' -METHYLENEBISBENZIMIDAZOLE DERIVATIVES FOR TREATING ISCHEMIA-RELATED NEURONAL DAMAGE<br/>[FR] COMPOSITIONS CONTENANT DES DERIVES DE 2, 2' METHYLENEBISBENZIMIDAZOLE PERMETTANT DE TRAITER LES DOMMAGES NEURONAUX LIES A L'ISCHEMIE
  申请人：ELAN PHARM INC

  公开号：WO2004066999A1

  公开（公告）日：2004-08-12

  2, 2’ -methylenebisbenzimidazole derived compounds, pharmaceutical compositions, and methods of use are described which are effective in inhibiting cell death, particularly apoptotic cell death. The compositions may be used for prevention and treatment of injuries associated with cell death, including ischemia, such as results from stroke or myocardial infarction, trauma, neurodegeneration, and inflammation.