3-(2-amino-6-oxo-1H-purin-9-yl)-N-(2-oxothiolan-3-yl)propanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-(2-amino-6-oxo-1H-purin-9-yl)-N-(2-oxothiolan-3-yl)propanamide
• 化学式: C₁₂H₁₄N₆O₃S
• 分子量: 322.35
• InChiKey: DEKMEWXZEWLGKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  157
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• SYNTHESIS AND METHODS OF USE OF 9-SUBSTITUTED GUANINE DERIVATIVES
  申请人：Neotherapeutics, Inc.

  公开号：EP1237890A1

  公开（公告）日：2002-09-11
• US6297226B1
  申请人：——

  公开号：US6297226B1

  公开（公告）日：2001-10-02
• [EN] SYNTHESIS AND METHODS OF USE OF 9-SUBSTITUTED GUANINE DERIVATIVES<br/>[FR] SYNTHESE ET PROCEDES D'UTILISATION DE DERIVES DE GUANINE 9-SUBSTITUES
  申请人：NEOTHERAPEUTICS INC

  公开号：WO2001029039A1

  公开（公告）日：2001-04-26

  The present invention is directed to 9-substituted guanine derivatives in which the guanine moiety is linked to another moiety with physiological or pharmacological activity through a carboxamide linkage. The number of carbon atoms between the guanine moiety and the carboxamide linking group is typically from 1 to 6. In some cases, the chemical moieties can have carbon chains of different lengths within the moiety linked to guanine through the carboxamide linker. A large number of different chemical moieties can be linked to the guanine moiety. The invention also includes pharmaceutical compositions including the 9-substituted guanine derivatives and methods of use of the 9-substituted guanine derivatives.