N-[2-(4-fluorophenyl)-3-pyridin-3-ylpropyl]-2-[4-[(2-fluorophenyl)sulfonylamino]piperidin-1-yl]acetamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[2-(4-fluorophenyl)-3-pyridin-3-ylpropyl]-2-[4-[(2-fluorophenyl)sulfonylamino]piperidin-1-yl]acetamide
• 化学式: C₂₇H₃₀F₂N₄O₃S
• 分子量: 528.6
• InChiKey: DPPIGTRYLZOFQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  37
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  99.8
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• AMINE AND AMIDE DERIVATIVES AS LIGANDS FOR THE NEUROPEPTIDE Y Y5 RECEPTOR USEFUL IN THE TREATMENT OF OBESITY AND OTHER DISORDERS
  申请人：Ortho-McNeil Pharmaceutical, Inc.

  公开号：EP1202986A1

  公开（公告）日：2002-05-08
• [EN] AMINE AND AMIDE DERIVATIVES AS LIGANDS FOR THE NEUROPEPTIDE Y Y5 RECEPTOR USEFUL IN THE TREATMENT OF OBESITY AND OTHER DISORDERS<br/>[FR] DERIVES D'AMINES ET D'AMIDES UTILISES EN TANT QUE LIGANDS POUR LE RECEPTEUR Y5 DU NEUROPEPTIDE Y, UTILE DANS LE TRAITEMENT DE L'OBESITE ET D'AUTRES TROUBLES
  申请人：ORTHO MCNEIL PHARM INC

  公开号：WO2001009120A1

  公开（公告）日：2001-02-08

  Amine and amide derivatives of formula (A) which are ligands for the neuropeptide Y Y5 (NPY5) receptor, methods of preparation and pharmaceutical compositions containing amines and amides of formula (A) as the active ingredient are described. The amines and amides of formula (A) are useful in the treatment of disorders and diseases associated with NPY receptor subtype Y5.