(1α,2β,5β)-(1-Aminomethyl-2,5-dimethyl-cyclopentyl)-acetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (1α,2β,5β)-(1-Aminomethyl-2,5-dimethyl-cyclopentyl)-acetic acid
• 英文别名: (1α,2α,5α)-(1-Aminomethyl-2,5-dimethyl-cyclopentyl)-acetic acid；(2R,5R)-(1-Aminomethyl-2,5-dimethyl-cyclopentyl)-acetic acid；2-[1-(Aminomethyl)-2,5-dimethylcyclopentyl]acetic acid
• 化学式: C₁₀H₁₉NO₂
• 分子量: 185.266
• InChiKey: VVJFYFLGWOCDQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Combinations of an alpha-2-delta ligand with a selective inhibitor of cyclooxygenase-2
  申请人：——

  公开号：US20030199567A1

  公开（公告）日：2003-10-23

  The invention relates to a combination, comprising a selective inhibitor of COX-2, or a pharmaceutically acceptable salt thereof, and an Alpha-2-delta ligand, or a pharmaceutically acceptable salt thereof, and valdecoxib. Examples of selective inhibitors of COX-2 include valdecoxib, rofecoxib, and celecoxib. Examples of Alpha-2-delta ligands include gabapentin, pregabalin, (3S,4S)-( 1 -Aminomethyl-3,4-dimethyl-cyclopentyl)-acetic acid, and 3-(1-aminomethyl-cyclohexylmethyl)-4H-[1,2,4]oxadiazol-5-one hydrochloride. The combinations are useful for treating certain diseases including cartilage damage, inflammation, pain, and arthritis.

  本发明涉及一种组合物，包括COX-2的选择性抑制剂或其药学上可接受的盐，以及Alpha-2-delta配体或其药学上可接受的盐和瓦尔德考昔。 COX-2的选择性抑制剂的例子包括瓦尔德考昔，罗非昔布和塞来昔布。 Alpha-2-delta配体的例子包括加巴喷丁，普拉巴林，（3S，4S）-（1-氨甲基-3,4-二甲基-环戊基）-乙酸和3-（1-氨甲基-环己基甲基）-4H-[1,2,4]噁二唑-5-酮盐酸盐。该组合物可用于治疗某些疾病，包括软骨损伤，炎症，疼痛和关节炎。
• Cyclic amino acids and derivatives thereof useful as pharmaceutical agents
  申请人：Bryans Stephen Justin

  公开号：US20050159487A1

  公开（公告）日：2005-07-21

  The invention is a novel series of cyclic amino acids which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), and inflammation, especially arthritis. A pharmaceutical composition containing a compound of the invention as well as methods of preparing the compounds and novel intermediates useful in the preparation of the final compounds are included.

  这项发明是一系列新型的环状氨基酸，可用于治疗癫痫、晕厥发作、神经退行性疾病、抑郁症、焦虑症、惊恐症、疼痛、神经病理性疾病、胃肠疾病如肠易激综合征（IBS）和炎症，尤其是关节炎。包括一种含有该发明化合物的药物组合物，以及制备该化合物的方法和制备最终化合物有用的新型中间体。
• PHARMACEUTICAL USES FOR ALPHA2DELTA LIGANDS
  申请人：Dooley James David

  公开号：US20070213401A1

  公开（公告）日：2007-09-13

  The invention relates to a method of treating central nervous system disorders and other disorders by administering an alpha2delta ligand such as, for example, a compound of the formula or a pharmaceutically acceptable salt thereof, wherein R 1 is hydrogen or straight or branched lower alkyl, and n is an integer of from 4 to 6.

  该发明涉及一种通过给予α2δ配体来治疗中枢神经系统疾病和其他疾病的方法，例如给予公式中的化合物或其药学上可接受的盐，其中R1为氢或直链或支链低碳基，n为4到6的整数。
• Gabapentin analogues for sleep disorders
  申请人：——

  公开号：US20030212133A1

  公开（公告）日：2003-11-13

  The invention provides a new use of compounds for formula 1 or 1A or a pharmaceutically acceptable salt thereof. The compounds are useful in the treatment of insomnia and related disorders. 1

  该发明提供了化合物1或1A或其药学上可接受的盐的新用途。这些化合物可用于治疗失眠和相关疾病。
• US7122678B2
  申请人：——

  公开号：US7122678B2

  公开（公告）日：2006-10-17