(Z)-3-cyano-5-methylhex-3-enoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Z)-3-cyano-5-methylhex-3-enoic acid
• 化学式: C₈H₁₁NO₂
• 分子量: 153.18
• InChiKey: HZHBIPCFTRPWKY-CLTKARDFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  61.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• C1-symmetric bisphosphine ligands and their use in the asymmetric synthesis of pregabalin
  申请人：Bao Jian

  公开号：US20050228190A1

  公开（公告）日：2005-10-13

  Materials and methods for preparing (S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid and structurally related compounds via enantioselective hydrogenation of prochiral olefins are disclosed. The methods employ novel chiral catalysts, which include C 1 -symmetric bisphosphine ligands bound to transition metals.

  通过对原生手性烯烃进行对映选择性加氢制备(S)-(+)-3-(氨甲基)-5-甲基己酸及其结构相关化合物的材料和方法已被披露。这些方法采用了新颖的手性催化剂，其中包括与过渡金属结合的C1对称双膦配体。
• Asymmetric synthesis of pregabalin
  申请人：——

  公开号：US20030212290A1

  公开（公告）日：2003-11-13

  This invention provides a method of making (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid (pregabalin) or a salt thereof via an asymmetric hydrogenation synthesis. Pregabalin is useful for the treatment and prevention of seizure disorders, pain, and psychotic disorders. The invention also provides intermediates useful in the production of pregabalin.

  该发明提供了一种通过不对称氢化合成制备(S)-(+)-3-(氨甲基)-5-甲基己酸（盐酸普拉巴林）或其盐的方法。盐酸普拉巴林对于治疗和预防癫痫、疼痛和精神疾病很有用。该发明还提供了在生产盐酸普拉巴林过程中有用的中间体。
• Synthesis of P-chiral bisphospholane ligands and their transition metal complexes for use as asymmetric hydrogenation catalysts
  申请人：——

  公开号：US20020087017A1

  公开（公告）日：2002-07-04

  P-chiral bisphospholane ligands and methods for their preparation are described. Use of metal/P-chiral bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.

  描述了P-手性双膦酸配体及其制备方法。还描述了利用金属/P-手性双膦酸配合物催化不对称转化反应，以提供形成化合物的高对映体选择性过量。
• Non-C2-symmetric bisphosphine ligands as catalysts for asymmetric hydrogenation
  申请人：——

  公开号：US20030073868A1

  公开（公告）日：2003-04-17

  Non-C 2 -symmetric bisphospholane ligands and methods for their preparation are described. Use of metal/non-C 2 -symmetric bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.

  本文描述了非C2对称的双膦酰胺配体及其制备方法。同时还描述了利用金属/非C2对称的双膦酰胺配合物催化不对称转化反应，提供高对映体过量形成化合物的方法。
• Synthesis of non-C2-symmetric bisphosphine ligands as catalysts for asymmetric hydrogenation
  申请人：——

  公开号：US20020143214A1

  公开（公告）日：2002-10-03

  Non-C 2 -symmetric bisphospholane ligands and methods for their preparation are described. Use of metal/non-C 2 -symmetric bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.

  本文描述了非C2对称的双膦酰胺配体及其制备方法。同时，本文还描述了使用金属/非C2对称的双膦酰胺配合物催化不对称转化反应，从而提供高对映选择性的形成化合物。