6-amino-N-[3-[4-(3-aminopropylamino)butylamino]propyl]hexanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-amino-N-[3-[4-(3-aminopropylamino)butylamino]propyl]hexanamide
• 化学式: C₁₆H₃₇N₅O
• 分子量: 315.5
• InChiKey: JFRBSNRODPYGHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  22
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  105
• 氢给体数：
  5
• 氢受体数：
  5

文献信息

• Novel polyamine analogues as therapeutic and diagnostic agents
  申请人：ORIDIGM CORPORATION

  公开号：EP1085011A1

  公开（公告）日：2001-03-21

  Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating disease where it is desired to inhibit polyamine transport or other polyamine binding proteins, for example cancer and post-angioplasty injury. Novel chemical synthetic methods to obtain polyamine analogues are disclosed, including the production of a combinatorial polyamine library. These approaches yield analogues with desirable activities both for diagnostic and research assays and therapy. The assays of the invention are useful for high throughput screening of targets in the discovery of drugs that interact with the polyamine system.

  本发明揭示了具有比已知化合物低两个数量级的抑制常数的多胺转运抑制剂。这些多胺类似物是治疗需要抑制多胺转运或其他多胺结合蛋白的疾病的有用药物，例如癌症和血管成形术后的损伤。揭示了获得多胺类似物的新的化学合成方法，包括制备组合多胺库。这些方法产生的类似物具有理想的诊断和研究测定和治疗活性。本发明的测定方法对于高通量筛选与多胺系统相互作用的药物发现目标非常有用。
• Polyamine analogues as therapeutic and diagnostic agents
  申请人：MediQuest Therapeutics, Inc.

  公开号：EP1867633A1

  公开（公告）日：2007-12-19

  Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins, for example cancer and post-angioplasty injury. Novel chemical synthetic methods to obtain polyamine analogues are disclosed, including the production of a combinatorial polyamine library. These approaches yield analogues with desirable activities both for diagnostic and research assays and therapy. The assays of the invention are useful for high throughput screening of targets in the discovery of drugs that interact with the polyamine system.

  本研究公开了新型多胺转运抑制剂，其抑制常数比已知化合物的抑制常数低两个数量级。这些多胺类似物是治疗需要抑制多胺转运或其他多胺结合蛋白的疾病（如癌症和血管成形术后损伤）的有用药物。公开了获得多胺类似物的新型化学合成方法，包括组合多胺库的生产。这些方法产生的类似物具有理想的活性，既可用于诊断和研究测定，也可用于治疗。本发明的检测方法可用于高通量筛选目标，以发现与多胺系统相互作用的药物。
• US6172261B1
  申请人：——

  公开号：US6172261B1

  公开（公告）日：2001-01-09
• US7160923B1
  申请人：——

  公开号：US7160923B1

  公开（公告）日：2007-01-09
• US7208528B1
  申请人：——

  公开号：US7208528B1

  公开（公告）日：2007-04-24