7-phenyl-2,3,7,8,9,10,11,12-octahydro-1H-azepino[4,5-b]pyrano[3,2-e]indole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 7-phenyl-2,3,7,8,9,10,11,12-octahydro-1H-azepino[4,5-b]pyrano[3,2-e]indole
• 英文别名: 11-Phenyl-6-oxa-11,15-diazatetracyclo[8.8.0.02,7.012,18]octadeca-1(10),2(7),8,12(18)-tetraene
• 化学式: C₂₁H₂₂N₂O
• 分子量: 318.418
• InChiKey: BGDUGJUQEVGVJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  26.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Azepino[4,5-b]pyrano[3,2-e]indoles
  申请人：——

  公开号：US20020022616A1

  公开（公告）日：2002-02-21

  1 wherein: R 1 -R 5 , m, n, p, and the bonds a and b represented by - - - have any of the values, specific values, or preferred values described in the specification; or a salt or solvate thereof. The invention also provides pharmaceutical compositions comprising such a compound, as well as intermediates and processes useful for preparing such a compound, and therapeutic methods including the administration of such a compound.

  本发明提供一种化合物，其中R1-R5，m，n，p和由- - -表示的键a和b具有规范中描述的任何值、具体值或优选值；或其盐或溶剂化物。本发明还提供包含这种化合物的药物组成物，以及用于制备这种化合物的中间体和方法，以及包括给予这种化合物的治疗方法。
• AZEPINO 4,5-B]PYRANO 3,2-E]INDOLES
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1296988A1

  公开（公告）日：2003-04-02
• US6503899B2
  申请人：——

  公开号：US6503899B2

  公开（公告）日：2003-01-07
• [EN] AZEPINO[4,5-B]PYRANO[3,2-E]INDOLES<br/>[FR] AZÉPINO[4,5-B]PYRANO[3,2-E]INDOLES
  申请人：UPJOHN CO

  公开号：WO2002004457A1

  公开（公告）日：2002-01-17

  The invetion provides a compound of formula (1), wherein: R1-R5, m, m, p, and the bonds a and b represented by --- have any of the values, specific values, or preferred values described in the specification; or a salt or solvate thereof. The invention also provides pharmaceutical compositions comprising such a compound, as well as intermediates and processes useful for preparing such a compound, and therapeutic methods including the administration of such a compound.