N-(2-hydroxyhexadecyl)-N-(2-hydroxyethyl)ethanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(2-hydroxyhexadecyl)-N-(2-hydroxyethyl)ethanamide
• 英文别名: N-(2-hydroxyethyl)-N-(2-hydroxyhexadecyl)acetamide
• 化学式: C₂₀H₄₁NO₃
• 分子量: 343.55
• InChiKey: XJXKJOUQWSEMDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  24
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  60.8
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Compositions for topical application to skin, hair and nails
  申请人：UNILEVER PLC

  公开号：EP0711558A1

  公开（公告）日：1996-05-15

  Compositions for treating skin, hair and nails which contain 25-hydroxycalciferol in combination with a lipid ingredient. The compositions avoid the toxic effects of 1,25-dihydroxycalciferol, yet attain keratinocyte differentiation and provide additional benefits. Also disclosed is a method of improving or preventing the appearance of wrinkled, flaky, aged, photodamaged skin by applying to skin a composition containing in a cosmetically acceptable vehicle 25-hydroxycalciferol and a lipid ingredient.

  含有25-羟基维生素D与脂质成分的用于治疗皮肤、头发和指甲的组合物。这些组合物避免了1,25-二羟基维生素D的毒性效应，同时实现了角质细胞分化并提供了额外的好处。还公开了一种通过在皮肤上涂抹含有25-羟基维生素D和脂质成分的化妆品可接受载体组合物来改善或预防出现皱纹、脱皮、老化、光损伤皮肤的方法。
• Water-based delivery systems
  申请人：——

  公开号：US20040009213A1

  公开（公告）日：2004-01-15

  The invention relates to a water-based delivery system for an active substance, characterized by enhancing skin barrier restoration in the stratum corneum comprising water, a fatty acid, cholesterol, a ceramide and at least one skin lipid precursor.

  本发明涉及一种以水为基础的有效物质输送系统，其特征在于增强角质层中皮肤屏障的修复，包括水、脂肪酸、胆固醇、酯化物和至少一种皮肤脂质前体。
• Compositions containing azole derivatives for topical application to skin
  申请人：UNILEVER PLC

  公开号：EP0747042B1

  公开（公告）日：2002-10-02
• WATER-BASED DELIVERY SYSTEMS
  申请人：Collagenex Pharmaceuticals, Inc.

  公开号：EP1534213A2

  公开（公告）日：2005-06-01
• EP1534213A4
  申请人：——

  公开号：EP1534213A4

  公开（公告）日：2005-10-26