Benzyl 2-[1-(benzamidomethyl)cyclohexyl]acetate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Benzyl 2-[1-(benzamidomethyl)cyclohexyl]acetate
• 化学式: C₂₃H₂₇NO₃
• 分子量: 365.5
• InChiKey: QCNDJDAWJJSMBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Cyclic amino acid derivatives useful as pharmaceutical agents
  申请人：——

  公开号：US20030216469A1

  公开（公告）日：2003-11-20

  Pro-drug compounds of the formula (I) or (II) and compositions containing them are provided that when administered to humans or other mammals provide an increased duration of active compound in the plasma compared to compounds of corresponding structure in which labile groups are not present. In the above formulae n, P, Q, R 1 , R 2 ; and R 3 ; are as defined in the specification. The compounds may be used to treat a range of neurological conditions. e.g. epilepsy or pain.

  提供了公式（I）或（II）的促药物化合物以及含有它们的组合物，当向人类或其他哺乳动物施用时，与相应结构中不含不稳定基团的化合物相比，在血浆中提供活性化合物的持续时间增加。在上述公式中，n、P、Q、R1、R2和R3如规范中所定义。这些化合物可用于治疗一系列神经疾病，例如癫痫或疼痛。
• CYCLIC AMINO ACID DERIVATIVES USEFUL AS PHARMACEUTICAL AGENTS
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1284960A1

  公开（公告）日：2003-02-26
• [EN] CYCLIC AMINO ACID DERIVATIVES USEFUL AS PHARMACEUTICAL AGENTS<br/>[FR] DERIVES D'ACIDES AMINES CYCLIQUES UTILES COMME AGENTS PHARMACEUTIQUES
  申请人：WARNER LAMBERT CO

  公开号：WO2001090052A1

  公开（公告）日：2001-11-29

  Pro-drug compounds of the formula (I) or (II) and compositions containing them are provided that when administered to humans or other mammals provide an increased duration of active compound in the plasma compared to compounds of corresponding structure in which labile groups are not present. In the above formulae n, P, Q, R?1, R2; and R3¿; are as defined in the specification. The compounds may be used to treat a range of neurological conditions, e.g. epilepsy or pain.