Calcium;3-(pentanoylamino)propane-1-sulfonate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Calcium;3-(pentanoylamino)propane-1-sulfonate
• 化学式: C16H32CaN2O8S2
• 分子量: 484.6
• InChiKey: JETHKSKFWHBREI-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  0.08
• 重原子数：
  29
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  189
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Orally administrable galenic form comprising metformine and an absorption-promoting agent
  申请人：MERCK PATENT GmbH

  公开号：EP1410791A1

  公开（公告）日：2004-04-21

  The present invention relates to an orally administrable galenic form allowing improved absorption by the transmembrane or paracellular route in the gastrointestinal tract of active ingredients which are hydrophilic or ionizable in physiological media, comprising at least one such active ingredient, an absorption-promoting agent having an HLB greater than 8, the said absorption-promoting agent consisting of one or more lipid substances chosen from: polysorbates; ethers of polyoxyethylene and alkyl; esters of polyoxyethylene and fatty acids; fatty acids; fatty alcohols; bile acids and their salts with pharmaceutically acceptable cations; esters of C1-C6 alkanol with fatty acids; esters of polyol with fatty acids, the said polyol comprising from 2 to 6 hydroxyl functional groups; and polyglycolysed glycerides; in combination with one or more pharmaceutically acceptable excipients, the pharmaceutical forms comprising captopril being excluded.

  本发明涉及一种可口服的galenic形式，可改善胃肠道对在生理介质中亲水性或可离子化的活性成分的跨膜或细胞旁途径吸收，该形式包括至少一种此类活性成分、一种HLB大于8的吸收促进剂，所述吸收促进剂由一种或多种脂质物质组成，这些脂质物质选自聚山梨醇酯；聚氧乙烯和烷基的醚；聚氧乙烯和脂肪酸的酯；脂肪酸；脂肪醇；胆汁酸及其与药学上可接受的阳离子的盐；C1-C6 烷醇与脂肪酸的酯；多元醇与脂肪酸的酯，所述多元醇包括 2 至 6 个羟基官能团；以及聚乙二醇化甘油酯；与一种或多种药学上可接受的赋形剂结合使用，不包括含有卡托普利的药剂。
• NOUVEAUX DERIVES D'ACIDES AMINOALKANE SULFONIQUES, PHOSPHONIQUES ET PHOSPHINIQUES, LEUR PREPARATION ET LEUR UTILISATION COMME MEDICAMENTS
  申请人：Merck Sante

  公开号：EP1051393B1

  公开（公告）日：2003-10-01
• ORALLY ADMINISTRABLE IMMEDIATE-RELEASE AND PROLONGED-RELEASE GALENIC FORM COMPRISING AN ABSORPTION-PROMOTING AGENT AND USE OF THIS ABSORPTION-PROMOTING AGENT
  申请人：MERCK PATENT GmbH

  公开号：EP1056445B1

  公开（公告）日：2004-06-02
• US6265437B1
  申请人：——

  公开号：US6265437B1

  公开（公告）日：2001-07-24
• US6426087B1
  申请人：——

  公开号：US6426087B1

  公开（公告）日：2002-07-30