1-N-[(2S,3R,4R)-3-hydroxy-4-(2-methoxyethoxy)-5-(2-methylpropylamino)-5-oxo-1-phenylpentan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-N-[(2S,3R,4R)-3-hydroxy-4-(2-methoxyethoxy)-5-(2-methylpropylamino)-5-oxo-1-phenylpentan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
• 化学式: C₃₃H₄₉N₃O₆
• 分子量: 583.8
• InChiKey: NDUKARZNWWQNJR-FRXPANAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  42
• 可旋转键数：
  18
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• US7354943B2
  申请人：——

  公开号：US7354943B2

  公开（公告）日：2008-04-08
• US7358264B2
  申请人：——

  公开号：US7358264B2

  公开（公告）日：2008-04-15
• [EN] ALPHA-HYDROXYAMIDE STATINE DERIVATIVES FOR THE TREATMENT OF ALZH EIMER'S DISEASE<br/>[FR] DERIVES DE STATINE ALPHA-HYDROXYAMIDE POUR LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：ELAN PHARM INC

  公开号：WO2003006021A1

  公开（公告）日：2003-01-23

  The present invention relates to compounds of formula (I): Useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment of reduce A beta peptide formation.