H-D-Phe-D-Phe-D-Leu-D-Orn-morpholide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-D-Phe-D-Phe-D-Leu-D-Orn-morpholide
• 英文别名: (2R)-N-[(2R)-5-amino-1-morpholin-4-yl-1-oxopentan-2-yl]-2-[[(2R)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanamide
• 化学式: C₃₃H₄₈N₆O₅
• 分子量: 608.8
• InChiKey: UJMGRNFQPVLBKU-CXDXLJMYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  44
• 可旋转键数：
  16
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  169
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• Synthetic peptide amides and dimers thereof
  申请人：CARA THERAPEUTICS, INC.

  公开号：US10913769B2

  公开（公告）日：2021-02-09

  The invention relates to synthetic peptide amide ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low P450 CYP inhibition and low penetration into the brain. The synthetic peptide amides of the invention conform to the structure: The compounds are useful in the prophylaxis and treatment of pain and inflammation associated with a variety of diseases and conditions.

  本发明涉及卡巴阿片受体的合成肽酰胺配体，特别是卡巴阿片受体的激动剂，这种激动剂表现出低 P450 CYP 抑制性和低脑穿透性。本发明的合成肽酰胺符合以下结构： 这些化合物可用于预防和治疗与多种疾病和病症相关的疼痛和炎症。
• Method For Elevating Prolactin in Mammals
  申请人：Menzaghi Frederique

  公开号：US20090312271A1

  公开（公告）日：2009-12-17

  Methods for elevating and stabilizing prolactin levels in a mammal including methods of treating disorders and conditions associated with reduced serum levels of prolactin are provided. Also provided are methods of using certain synthetic tetrapeptide amides which are peripherally selective kappa opioid receptor agonists to elevate or stabilize serum prolactin levels.
• Method For Elevating Prolactin In Mammals
  申请人：Menzaghi Frederique

  公开号：US20130012431A1

  公开（公告）日：2013-01-10

  Methods for elevating and stabilizing prolactin levels in a mammal including methods of treating disorders and conditions associated with reduced serum levels of prolactin are provided. Also provided are methods of using certain synthetic tetrapeptide amides which are peripherally selective kappa opioid receptor agonists to elevate or stabilize serum prolactin levels.
• US8217000B2
  申请人：——

  公开号：US8217000B2

  公开（公告）日：2012-07-10