(E)-3-cyano-5-methylhex-3-enoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-3-cyano-5-methylhex-3-enoic acid
• 化学式: C₈H₁₁NO₂
• 分子量: 153.18
• InChiKey: HZHBIPCFTRPWKY-XVNBXDOJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  61.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• C1-SYMMETRIC BISPHOSPHINE LIGANDS AND THEIR USE IN THE ASYMMETRIC SYNTHESIS OF PREGABALIN
  申请人：Warner-Lambert Company LLC

  公开号：EP1727620B1

  公开（公告）日：2007-08-29
• C1-Symmetric Bisphospine Ligands and Their Use in the Asymmetric Synthesis of Pregabalin
  申请人：Bao Jian

  公开号：US20090124820A1

  公开（公告）日：2009-05-14

  Materials and Methods for preparing (S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid and structurally related compounds via enantioselective hydrogenation of prochiral olefins are disclosed. The methods employ novel chiral catalysts, which include C 1 -symmetric bisphosphine ligands bound to transition metals.