4-Amino-5-oxo-5-(1,3-thiazolidin-3-yl)pentanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-Amino-5-oxo-5-(1,3-thiazolidin-3-yl)pentanamide
• 化学式: C₈H₁₅N₃O₂S
• 分子量: 217.29
• InChiKey: RZUGQATVTHRDBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  115
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels
  申请人：Pospisilik J. Andrew

  公开号：US20070207946A1

  公开（公告）日：2007-09-06

  The present invention provides new uses of DPIV-inhibitors of the present invention, and their corresponding pharmaceutically acceptable acid addition salt forms, for lowering blood pressure levels.

  本发明提供了本发明的DPIV抑制剂的新用途，以及它们对应的药学上可接受的酸盐形式，用于降低血压水平。
• USE OF DIPEPTIDYL PEPTIDASE IV INHIBITORS AS THERAPEUTICS FOR NEUROLOGICAL DISORDERS
  申请人：Probiodrug AG

  公开号：EP1399471B1

  公开（公告）日：2008-01-30
• SECONDARY BINDING SITE OF DIPEPTIDYL PEPTIDASE IV (DP IV)
  申请人：Prosidion Limited

  公开号：EP1543023B1

  公开（公告）日：2010-03-17
• INHIBITORS OF GLUTAMINYL CYCLASE
  申请人：Probiodrug AG

  公开号：EP1620091B1

  公开（公告）日：2010-03-31
• Methods for improving islet signaling in diabetes mellitus and for its prevention
  申请人：Demuth Hans-Ulrich

  公开号：US20070293426A1

  公开（公告）日：2007-12-20

  The present invention discloses methods for therapeutically treating mammals, including but not limited to humans, to increase the relative insulin producing performance of endogenous pancreatic β-cells, to cause differentiation of pancreatic epithelial cells into insulin producing β-cells, to improve muscle sensitivity to insulin and other weight control efforts by the chronic oral administration of a DP IV-inhibitor. The administration causes the active form of GLP-1 and other non-nutrient stimulated growth hormones to remain biologically active longer under physiological conditions. The extended presence of such hormones, in particular in the pancreatic tissue can also facilitate differentiation and regeneration of the β-cells already present that are in need of repair.