1-aminospiro[2H-indene-3,2'-cyclopropane]-1,1'-dicarboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-aminospiro[2H-indene-3,2'-cyclopropane]-1,1'-dicarboxylic acid
• 化学式: C₁₃H₁₃NO₄
• 分子量: 247.25
• InChiKey: JENCPKDLNYHSMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Novel spiro[2.4]heptane amino carboxy compounds and derivatives thereof
  申请人：——

  公开号：US20040077599A1

  公开（公告）日：2004-04-22

  The present invention relates to therapeutically active novel spiro[2,4]heptane amino carboxy compounds and derivatives thereof. Also provided is a method of preparing compounds of Formula (I), and pharmaceutical compositions comprising the compounds. The novel compounds act as modulators of metabotropic glutamate receptors and, as such, are useful in treating diseases of the central nervous system related to the metabotropic glutamate receptor system. 1

  本发明涉及治疗活性新的螺[2,4]庚烷氨基羧化合物及其衍生物。还提供了制备式(I)化合物的方法和包含该化合物的药物组合物。这些新的化合物作为代谢型谷氨酸受体的调节剂，因此在治疗与代谢型谷氨酸受体系统相关的中枢神经系统疾病方面是有用的。
• NOVEL SPIRO[2.4]HEPTANE AMINO CARBOXY COMPOUNDS AND DERIVATIVES THEREOF
  申请人：Curry, Kenneth

  公开号：EP1280760A1

  公开（公告）日：2003-02-05
• [EN] NOVEL SPIRO[2.4]HEPTANE AMINO CARBOXY COMPOUNDS AND DERIVATIVES THEREOF<br/>[FR] NOUVEAUX COMPOSES SPIRO[2.4]HEPTANE AMINO CARBOXY ET DERIVES ASSOCIES
  申请人：CURRY KENNETH

  公开号：WO2001085669A1

  公开（公告）日：2001-11-15

  The present invention relates to therapeutically active novel spiro[2.4]heptane amino carboxy compounds and derivatives thereof. Also provided is a method of preparing compounds of Formula (I), and pharmaceutical compositions comprising the compounds. The novel compounds act as modulators of metabotropic glutamate receptors and, as such, are useful in treating diseases of the central nervous system related to the metabotropic glutamate receptor system.