diethyl 5-formyl-3-phenyl-1H-pyrrole-2,4-dicarboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: diethyl 5-formyl-3-phenyl-1H-pyrrole-2,4-dicarboxylate
• 化学式: C₁₇H₁₇NO₅
• 分子量: 315.32
• InChiKey: BZXDSDUTLGPSLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  85.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• ANTIBODIES
  申请人：Sathyanarayanan Sriram

  公开号：US20120058112A1

  公开（公告）日：2012-03-08

  The combination of an IGF-1R antagonist such as a humanized antibody and an anti-proliferative drug is described. In a preferred embodiment, the present invention describes the combination of an IGF-1R antibody and an anti-proliferative drug belonging to the EGFR-inhibitor class, which is preferably erlotinib. The combination according to the present invention is useful for the treatment of tumours, including IGF-1R and/or EGFR mediated or dependent tumours.

  本发明描述了IGF-1R拮抗剂（例如人源化抗体）和抗增殖药物的组合。在一种优选实施方案中，本发明描述了IGF-1R抗体和属于EGFR抑制剂类的抗增殖药物（优选为厄洛替尼）的组合。根据本发明的组合对于治疗肿瘤，包括IGF-1R和/或EGFR介导或依赖的肿瘤是有用的。
• Methods and Compositions for Treating or Preventing Cancer
  申请人：MERCK SHARP & DOHME CORP.

  公开号：US20150093398A1

  公开（公告）日：2015-04-02

  This invention relates to compositions and methods useful for treating various cancers. Therapeutic combinations and methods of use thereof are also covered in the present application.

  本发明涉及用于治疗各种癌症的组合物和方法。本申请还涵盖了治疗组合物和使用方法。
• [EN] TYROSINE KINASE INHIBITORS<br/>[FR] INHIBITEURS DE LA TYROSINE KINASE
  申请人：MERCK & CO INC

  公开号：WO2003035614A2

  公开（公告）日：2003-05-01

  The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a 2-carboxy-5-formyl pyrrole. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.
• [EN] METHODS OF TREATMENT<br/>[FR] PROCÉDÉS DE TRAITEMENTS
  申请人：SCHERING CORP

  公开号：WO2008076278A2

  公开（公告）日：2008-06-26

  (EN) This invention relates to compositions and methods useful for treating various cancers. Therapeutic combinations and methods of use thereof are also covered in the present application.(FR) L'objet de la présente invention concerne des compositions et procédés pour traiter différents cancers. Les combinaisons et procédés thérapeutiques qui s'y rapportent sont également traités dans la présente invention.