N,N''-(heptane-1,7-diyl)dipropane-2-sulfonamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: N,N''-(heptane-1,7-diyl)dipropane-2-sulfonamide
• 英文别名: N-[7-(propan-2-ylsulfonylamino)heptyl]propane-2-sulfonamide
• 化学式: C₁₃H₃₀N₂O₄S₂
• 分子量: 342.5
• InChiKey: LIMYKOPCOXOSMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  21
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• (BIS)SULFONAMIDE DERIVATIVES
  申请人：ELI LILLY AND COMPANY

  公开号：EP1292571A2

  公开（公告）日：2003-03-19
• [EN] (BIS)SULFONAMIDE DERIVATIVES<br/>[FR] DERIVES DE (BIS)SULFONAMIDE
  申请人：LILLY CO ELI

  公开号：WO2001094306A2

  公开（公告）日：2001-12-13

  The present invention provides bissulphonamide derivatives of formula (I), in which R1 represents C¿1-6?-alkyl, C2-6-alkenyl, or NR?7R8,R2 and R3¿ each independently represent hydrogen, C¿1-4?.alkyl, F, aryl, or C1-6.alkylaryl; R?4 and R5¿ each represent hydrogen; R6 represents C¿1-6?-alkyl; n is an integer from 7 to 14; and R?7 and R8¿ each independently represent hydrogen or C¿1-4?-alkyl; or a pharmaceutically acceptable salt thereof. Bissulphonamide derivatives of formula (I), in which R?1¿ represents C¿1-6?-alkyl, C2-6-alkenyl, or NR?7R8, R2, R2, R4, and R5¿ each represent hydrogen; R6 represents C¿1-6?-alkyl; n is an integer from 6 to 14; and R?7 and R8¿ each independently represent hydrogen or C¿1-4?-alkyl; or a pharmaceutically acceptable salt thereof; are useful for potentiating glutamate receptor function in a mammal and, therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.