3-Chloro-4-[1,2,2-trifluoro-2-(trifluoromethoxy)ethoxy]aniline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-Chloro-4-[1,2,2-trifluoro-2-(trifluoromethoxy)ethoxy]aniline
• 化学式: C₉H₆ClF₆NO₂
• 分子量: 309.59
• InChiKey: WZBJXMBZQSVRPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Antimycotic compositions
  申请人：Novartis AG

  公开号：EP1080722A1

  公开（公告）日：2001-03-07

  Described is the excellent and safe antimycotic action of the compound of the formula (1) wherein Y is a completely or partially halogenated C1-C6alkyl or a completely or partially halogenated and with an oxygen atom interrupted C1-C6alkyl or a completely or partially halogenated C2-C6alkenyl; R1, R2, R3 and R4 are independently of each other hydrogen, halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6haloalkoxy, X1 is hydrogen or C1-C6alkyl, X2 is hydrogen or C1-C6alkyl. Further described are antimycotic compositions comprising as active ingredient at least one of said compounds, and to the use of said compounds and antimycotic compositions for the treatment of mycotic infections in humans or animals.

  描述了式(1)化合物卓越而安全的抗真菌作用 其中，Y 是完全或部分卤代的 C1-C6 烷基，或完全或部分卤代并有一个氧原子间断的 C1-C6 烷基，或完全或部分卤代的 C2-C6 烯基；R1、R2、R3 和 R4 相互独立地是氢、卤素、C1-C6 烷基、C1-C6 卤代烷基、C1-C6 卤代烷氧基，X1 是氢或 C1-C6烷基，X2 是氢或 C1-C6烷基。进一步描述了包含至少一种所述化合物作为活性成分的抗霉菌组合物，以及所述化合物和抗霉菌组合物用于治疗人类或动物的霉菌感染的用途。
• ANTIMYCOTIC DRUG
  申请人：Novartis AG

  公开号：EP1207869A2

  公开（公告）日：2002-05-29
• [EN] ANTIMYCOTIC DRUG<br/>[FR] MEDICAMENT ANTIMYCOSIQUE
  申请人：NOVARTIS AG

  公开号：WO2001015684A2

  公开（公告）日：2001-03-08

  Described is the excellent and safe antimycotic action of the compound of formula (I) wherein Y is a completely or partially halogenated C1-C6alkyl or a completely or partially halogenated and with an oxygen atom interrupted C1-C6alkyl or a completely or partially halogenated C2-C6alkenyl; R1, R2, R3 and R4 are independently of each other hydrogen, halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6haloalkoxy, X1 is hydrogen or C1-C6alkyl, X2 is hydrogen or C1-C6alkyl. Further described are antimycotic drugs comprising as active ingredient at least one of said compounds, and to the use of said compounds and antimycotic compositions for the treatment of mycotic infections in humans or animals.